无机生物材料在骨修复中的骨免疫调节作用

Osteoimmunomodulatory effects of inorganic biomaterials in the process of bone repair

目的 综述无机生物材料在骨修复过程中的骨免疫调节作用以及相关作用机制。方法 广泛查阅国内外相关文献,总结各类无机生物材料在骨修复过程中的作用特点,探讨其在该过程中的骨免疫作用机制。结果 免疫细胞在骨组织动态平衡中扮演重要角色。无机生物材料通过改变自身表面粗糙度、表面润湿性等理化特性可以直接调控机体内的免疫细胞,构建适宜的免疫微环境,进而实现对成骨过程的动态调控。结论 无机生物材料是一类广泛应用于骨修复的生物材料,充分认识材料在骨修复过程中的骨免疫调节作用,有助于设计新型骨免疫调节支架用于骨修复。

Objective To review the osteoimmunomodulatory effects and related mechanisms of inorganic biomaterials in the process of bone repair. Methods A wide range of relevant domestic and foreign literature was reviewed, the characteristics of various inorganic biomaterials in the process of bone repair were summarized, and the osteoimmunomodulatory mechanism in the process of bone repair was discussed. Results Immune cells play a very important role in the dynamic balance of bone tissue. Inorganic biomaterials can directly regulate the immune cells in the body by changing their surface roughness, surface wettability, and other physical and chemical properties, constructing a suitable immune microenvironment, and then realizing dynamic regulation of bone repair. Conclusion Inorganic biomaterials are a class of biomaterials that are widely used in bone repair. Fully understanding the role of inorganic biomaterials in immunomodulation during bone repair will help to design novel bone immunomodulatory scaffolds for bone repair.