厚朴排气合剂治疗脓毒症急性胃肠损伤患者的临床研究

Clinical study of Houpo Paiqi Mixture in the treatment of patients with sepsis acute gastrointestinal injury

目的探讨厚朴排气合剂治疗脓毒症急性胃肠损伤患者的临床效果。方法选择2020年4月至2021年5月安徽中医药大学第一附属医院重症医学科住院的脓毒症急性胃肠损伤患者40例作为研究对象,按随机数字表法将其分为对照组和干预组,每组20例,对照组予西医常规治疗,干预组在对照组的基础上加用厚朴排气合剂治疗,7 d为一个疗程。观察两组降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、肠鸣音次数、肠内营养量、序贯器官衰竭(SOFA)评分、急性生理与慢性健康评分Ⅱ(APACHEⅡ)的变化情况,以及临床疗效。结果治疗后两组hs-CRP、PCT较治疗前降低,且干预组低于对照组(P<0.05);治疗后两组肠鸣音次数、肠内营养量较治疗前升高,且干预组高于对照组(P<0.05);治疗后两组SOFA评分、APACHEⅡ评分较治疗前降低,且干预组低于对照组(P<0.05);干预组临床疗效优于对照组(P<0.05)。结论厚朴排气合剂治疗脓毒症急性胃肠损伤患者,优于单纯西医治疗,能够减轻炎症反应,改善胃肠道功能,降低患者病情危重程度,改善预后。

Objective To explore the clinical effect of Houpo Paiqi Mixture in the treatment of patients with sepsis acute gastrointestinal injury.Methods A total of 40 patients with sepsis acute gastrointestinal injury hospitalized in the Department of Critical Care Medicine of the First Affiliated Hospital of Anhui University of Chinese Medicine from April 2020 to May 2021 were selected as the research objects.They were divided into control group and intervention group according to random number table method,with 20 cases in each group,the control group was treated with conventional Western medicine,the intervention group was treated with Houpo Paiqi Mixture on the basis of the control group,7 days for a course of treatment.The changes of procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP),the number of bowel sounds,enteral nutrition,sequential organ failure assessment score(SOFA),acute physiology and chronic health score Ⅱ(APACHEⅡ),and clinical effects were observed in the two groups.Results After treatment,hS-CRP and PCT in the two groups were lower than those before treatment,and the intervention group was lower than those in the control group(P<0.05).After treatment,the frequency of bowel sounds and enteral nutrition in the two groups were higher than those before treatment,and the intervention group was higher than those in the control group(P<0.05).After treatment,SOFA score and APACHEⅡ score of the two groups were lower than those before treatment,and the intervention group was lower than those in the control group(P<0.05).The clinical effect of intervention group was better than that in the control group(P<0.05).Conclusion Houpo Paiqi Mixture for patients with sepsis acute gastrointestinal injury is better than simple treatment of Western medicine,can reduce inflammatory reaction,improve gastrointestinal function,reduce the degree of critical illness,also improve the prognosis.