复方谷氨酰胺肠溶胶囊辅助治疗溃疡性结肠炎患者的效果及对患者胃肠功能康复的影响

The effect of Compound Glutamine Enteric-coated Capsules in adjuvant treatment of patients with ulcerative colitis and its influence on the rehabilitation of patients′gastrointestinal function

目的研究复方谷氨酰胺肠溶胶囊辅助治疗溃疡性结肠炎(UC)患者的临床效果,以及对患者胃肠功能康复的促进效果。方法选取2018年3月至2021年3月江门市中心医院消化内科收治的92例UC患者作为研究对象,采用随机数字表法将其分为试验组(n=46)和对照组(n=46)。试验组患者采用美沙拉嗪+复方谷氨酰胺肠溶胶囊治疗,对照组患者采用美沙拉嗪治疗。比较两组患者的治疗效果与不良反应发生率、治疗前后肠屏障功能和胃肠功能康复指标差异。结果试验组治疗总有效率(95.65%)高于对照组(82.61%),差异有统计学意义(P<0.05);治疗后,试验组二胺氧化酶、D-乳酸、细菌内毒素水平均低于对照组,差异有统计学意义(P<0.05);试验组结肠镜下评分、改良梅奥评分(Mayo)低于对照组,胃肠道生活质量指数(GIQLI)高于对照组,差异有统计学意义(P<0.05);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论复方谷氨酰胺肠溶胶囊辅助美沙拉嗪治疗溃疡性结肠炎,能有效提升患者治疗效果且安全性良好,对改善溃疡性结肠炎患者的肠屏障功能、抑制患者肠黏膜病情进展、降低患者疾病相关影响、优化患者胃肠系统相关生活质量均有良好效果,对促进溃疡性结肠炎患者胃肠功能康复具有积极价值,值得推广。

Objective To study the clinical effect of Compound Glutamine Enteric-Coated Capsules on patients with ulcerative colitis(UC)and the rehabilitation effect on gastrointestinal function.Methods Ninety-two UC patients in the Department of Gastroenterology of Jiangmen Central Hospital from March 2018 to March 2021 were selected as the research objects,and they were divided into an experimental group(n=46)and a control group(n=46)by the random number table method.Patients in the experimental group were treated with Mesalamine+Compound glutamine enteric-coated capsules,and patients in the control group were treated with Mesalamine.The treatment effect and the incidence of adverse reactions,the intestinal barrier function and gastrointestinal function rehabilitation indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group(95.65%)was higher than that in the control group(82.61%),and the difference was statistically significant(P<0.05).After treatment,the levels of diamine oxidase,D-lactic acid and bacterial endotoxin in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).The colonoscopy score and modified Mayo score(Mayo)in the experimental group were lower than those in the control group,and the gastrointestinal quality of life index(GIQLI)was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compound Glutamine Enteric-Coated Capsules combined with Mesalazine in the treatment of ulcerative colitis can effectively improve the therapeutic effect of patients without good safety.It has a good effect on improving the intestinal barrier function of patients with ulcerative colitis,inhibiting the progress of intestinal mucosa,reducing the disease-related impact of patients,and optimizing the quality of life related to gastrointestinal system.It has a positive value in promoting the rehabilitation of gastrointestinal function in patients with ulcerative colitis.