小剂量奥氮平联合文拉法辛对重度抑郁症急性期患者疗效的影响

Therapeutic effect of low-dose Olanzapine combined with Venlafaxine on patients with acute major depression

目的探讨小剂量奥氮平联合文拉法辛对重度抑郁症急性期患者疗效的影响。方法选取2019年5月至2020年5月营口市第四人民医院收治的94例重度抑郁症急性期患者作为研究对象,采用随机数字表法将其分为研究组和参照组,每组各47例。参照组患者选用文拉法辛口服治疗,研究组患者则在文拉法辛的基础上联合小剂量奥氮平治疗。比较两组患者治疗前及治疗2、4、8、16周的汉密尔顿抑郁量表(HAMD)评分,比较两组患者的临床疗效及不良反应总发生率。结果治疗前,两组患者的HAMD评分比较,差异无统计学意义(P>0.05);两组患者治疗2、4、8、16周的HAMD评分均低于治疗前,差异有统计学意义(P<0.05)。研究组患者治疗2、4、8、16周的HAMD评分均低于参照组,差异有统计学意义(P<0.05)。研究组患者的总有效率高于参照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在文拉法辛的基础上联合小剂量奥氮平治疗重度抑郁症急性期患者,能提升患者的临床治疗效果,有助于更快地控制抑郁症状,且未增加不良反应。

Objective To investigate the therapeutic effect of low-dose Olanzapine combined with Venlafaxine on acute phase of patients with acute major depression.Methods A total of 94 patients with acute major depression admitted to the Fourth People′s Hospital of Yingkou City from May 2019 to May 2020 were selected as the research subjects.They were divided into study group and reference group by random number table method,with 47 patients in each group.The reference group was treated with Venlafaxine orally,while the study group was treated with low-dose Olanzapine on the basis of Venlafaxine.The Hamilton depression scale(HAMD)scores before treatment and at 2,4,8 and 16 weeks after treatment of the two groups were compared,the clinical efficacy and total incidence of adverse reactions in the two groups were compared.Results Before treatment,there were no significant differences in HAMD scores between the two groups(P>0.05).HAMD scores of 2,4,8 and 16 weeks after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P<0.05).The HAMD scores at 2,4,8 and 16 weeks after treatment of the study group were lower than those of the reference group,with statistical significances(P<0.05).The total effective rate of study group was higher than that of reference group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Venlafaxine and low-dose Olanzapine in the treatment of patients with acute major depression can improve the clinical treatment effect and help to control depressive symptoms more quickly without increasing adverse reactions.