Elabela在子痫前期中的研究进展

Research Progress of Elabela in Pre-Eclampsia

子痫前期是孕产妇及新生儿死亡的主要原因之一,目前其发病机制仍不清楚。Elabela是一种新发现的Apelin受体(APJ)的内源性配体。Elabela和Apelin共有少量的类似序列,表现出相似的生物学作用,参与人类多种疾病的发生,如急性肾损伤、心力衰竭、糖尿病、高血压、胎儿发育异常和肿瘤等。与APJ的第一个配体Apelin相比,Elabela在孕妇的血清、胎盘、尿液及胎儿脐带血中均有表达。Elabela参与胚胎心血管系统的形成和胎盘的早期发育,在子痫前期的发病中发挥关键作用。综述Elabela的结构、生物学功能及其与子痫前期发病的关系,并探讨Elabela参与子痫前期发病的可能机制,包括参与胎盘滋养细胞侵袭、血管生成和损伤母体血管内皮细胞。

Pre-eclampsia is one of the main causes of maternal and neonatal death.At present,the pathogenesis is still unclear.Elabela is a newly discovered endogenous peptide ligand of Apelin receptor(APJ).Elabela and Apelin have a small number of similar sequences,showing similar biological effects,which are involved in many kinds of human diseases,such as acute kidney injury,heart failure,diabetes,hypertension,fetal dysplasia,tumor and so on.Compared with Apelin,the first ligand of APJ,Elabela can be detected in maternal serum,placenta,urine and fetal umbilical cord blood.Elabela participates in the formation of embryonic cardiovascular system and the early development of placenta,and plays a key role in the pathogenesis of pre-eclampsia.In this review,we summarize the structure and biological function of Elabela and its relationship with the pathogenesis of pre-eclampsia,and discusses the possible mechanism of Elabela′s involvement in the pathogenesis of pre-eclampsia,including the invasion of placental trophoblast,angiogenesis and damage to maternal vascular endothelial cells.