摘要
胃癌是我国最常见的消化道肿瘤,治疗效果欠佳。已发现的RNA修饰方式超过150种,而m^(6)A的动态修饰是RNA修饰中丰度最高的方式。m^(6)A修饰在RNA代谢中扮演重要角色,且参与到细胞的增殖、分化和凋亡等多种生物学过程中。在胃癌的发生发展中m^(6)A修饰失衡也发挥重要作用,深入研究胃癌的分子机制能为胃癌的治疗提供新的策略。
Gastric cancer is the most common gastrointestinal tumor in China,and its therapeutic effect is not good.More than 150 kinds of RNA modifications have been discovered,and the dynamic modification of m^(6)A is the most abundant one in RNA modification.m^(6)A modification plays an important role in RNA metabolism and is involved in many biological processes such as cell proliferation,differentiation,and apoptosis.m^(6)A modification imbalance also plays an important role in the occurrence and development of gastric cancer,in-depth study of the molecular mechanism of gastric cancer can provide a new strategy for the treatment of gastric cancer.
作者
谢生茂
张志龙
李春卉
石菲
XIE Shengmao;ZHANG Zhilong;LI Chunhui;SHI Fei(Department of Gastroenterology,NO.969 Hospital,the Chinese People’s Liberation Army Joint Logistic Support Force,Inner Mongolia Autonomous Region,Hohhot 010051,China;Department of General Surgery,NO.969 Hospital,the Chinese People’s Liberation Army Joint Logistic Support Force,Inner Mongolia Autonomous Region,Hohhot 010051,China;Department of Respiratory and Critical Care Medicine,Inner Mongolia People’s Hospital,Inner Mongolia Autonomous Region,Hohhot 010010,China;School of Medicine of Aeronautics and Astronautics,the Chinese People’s Liberation Army Air Force Medical University,Shaanxi Province,Xi’an 710032,China)
出处
《中国医药导报》
CAS
2022年第10期42-45,共4页
China Medical Herald
基金
国家自然科学基金资助项目(31971171)。
