基于数据挖掘的中医药治疗气虚血瘀证慢性萎缩性胃炎用药规律研究

Study on the medication rules of traditional Chinese medicine in the treatment of chronic atrophic gastritis with the syndrome of qi deficiency and blood stasis based on data mining

目的利用中医传承辅助平台挖掘中医药治疗气虚血瘀证慢性萎缩性胃炎(CAG)的用药规律。方法检索中国知网、万方和维普数据库1990年1月至2020年12月中医药治疗气虚血瘀证CAG的相关文献,从筛选的文献中提取中药处方,利用中医传承辅助平台对药物进行频次分析、关联规则分析和聚类分析。结果共获得中药处方166首,涉及155种中药,其中药性以温性为主,药味以甘味为主,归经以脾经为主。使用频次≥30次的中药有20种。关联规则分析得到63个药物组合与10个药物配伍规则,关联规则显示药物组合为六君子汤加味。聚类分析得到核心药物组合16个,新方8个。结论气虚血瘀证CAG治疗用药以益气健脾为基础,以活血化瘀为核心,兼以清热解毒;新方以补虚扶正、化瘀解毒为主,以理气、消食为辅。

Objective To explore the medication rules of traditional Chinese medicine in the treatment of chronic atrophic gastritis(CAG)with the syndrome of qi deficiency and blood stasis by using traditional Chinese medicine inheritance auxiliary platform.Methods The literature in the treatment of CAG with the syndrome of qi deficiency and blood stasis from January 1990 to December 2020 were collected through the CNKI,Wanfang,and VIP databases,and prescriptions were extracted from the screened literatures.The traditional Chinese medicine inheritance auxiliary platform was used to perform frequency analysis,association rule analysis,and cluster analysis on the drugs.Results A total of 166 prescriptions were selected,involving 155 kinds of Chinese herbs,among them,the drug properties was mainly warm,the drug taste was mainly sweet,and the meridian tropism was mainly spleen meridian.There were 20 Chinese herbs with frequency more than 30.A total of 63 drug combinations and 10 drug compatibility rules were obtained by association rule analysis,association rule diagram showed that the drug combination was modified Liujunzi Decoction.A total of 16 core drug combinations and eight new prescriptions were obtained by cluster analysis.Conclusion The treatment of CAG with the syndrome of qi deficiency and blood stasis is based on replenishing qi and invigorating spleen,with the core of activating blood and removing stasis,combining with learing heat and removing toxicity;the new prescription is mainly based on tonifying deficiency and strengthening vital qi,removing stasis and removing toxicity,supplemented by regulating qi and digesting food.