基于数据挖掘谢作钢教授治疗慢性前列腺炎用药规律研究

Research on the medication rule of Professor Xie Zuogang in the treatment of chronic prostatitis based on data mining

目的研究谢作钢教授治疗慢性前列腺炎的用药规律。方法选择2019年1月至2020年8月浙江省温州市中西医结合医院男科门诊谢作钢教授治疗慢性前列腺炎的病历资料,建立相关数据库,采用频数分析、关联规则分析、熵聚类分析法挖掘处方中相关的核心药物组合及隐藏于处方中的药物配伍规律。结果本研究共纳入356例病例,共纳入处方1015首,涉及药物267种。药物四气以寒、温为主,五味多用苦、辛为主,常用归经多为肝经。使用频次在220种以上的有23味药物,前五位分别是茯苓、桂枝、炙甘草、黄芩、柴胡。通过关联规则分析挖掘核心处方。基于复杂系统熵聚类分析,演化出12个中药核心组合和6首新处方。结论谢作钢教授运用中医药治疗前列腺炎治法上多以“疏肝理气”“活血化瘀”“清热利湿”“补肾益气”为主。

Objective To study the medication rule of Professor Xie Zuogang in the treatment of chronic prostatitis.Methods The medical records of Professor Xie Zuogang in the andrology clinic of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Zhejiang Province from January 2019 to August 2020 were selected,the relevant database was established,and the relevant core drug combinations and drug compatibility laws hidden in the prescription were mined by frequency analysis,association rule analysis,and entropy cluster analysis.Results A total of 356 cases and 1015 prescriptions were included in this study,involving 267 kinds of drugs.The four Qi of medicine were mainly cold and warm,and the five flavours were mainly bitter and pungent.The commonly used channel tropism was mainly liver meridian.There were 23 drugs used more than 220 times,and the top five were Poria,Ramulus Cinnamomi,Radix Glycyrrhizae,Radix Scutellariae,and Radix Bupleuri.Core prescriptions were mined through association rule analysis.Based on entropy cluster analysis of complex system,12 core combinations of traditional Chinese medicine and six new prescriptions were evolved.Conclusion Professor Xie Zuogang’s treatment of prostatitis with traditional Chinese medicine mainly focuses on“soothing liver and regulating qi”,“activating blood and removing stasis”,“clearing heat and promoting diuresis”,and“tonifying kidney and benefiting qi”.