基于数据挖掘分析赵海滨教授治疗双心疾病的组方规律及用药经验

Analysis of Professor Zhao Haibin’s formulation rules and medication experience in the treatment of psycho-cardiological disease based on data mining

目的基于数据挖掘技术,分析赵海滨教授治疗双心疾病的组方规律及用药经验。方法将2018年1月至2021年4月赵海滨教授治疗双心疾病的194首处方录入中医辅助传承平台(V2.5)系统,采用关联规则、层次聚类等算法,从药物频次、四气五味及归经、核心组合和潜在新方等多方面进行数据挖掘。结果194首处方共包含148味中药,以温、寒、平味药多见,辛、苦、甘味药较为常用,归经以脾、肺、胃、肝及心经为主,使用频次前三的中药为半夏、茯苓、桂枝。共得到22组药对组合,白术和茯苓的关联度最高,挖掘出22个由3味药组成的核心组合,并得到4首新方组合。结论赵海滨教授治疗双心疾病重视调畅气机,常用理气清热、化痰利水、补益气血、活血通络及安神之法,注重标本兼顾和通补兼施。

Objective To analyze the rule of Professor Zhao Haibin’s formulation rules and experience in the treatment of psycho-cardiological disease based on data mining technology.Methods A total of 194 prescriptions for psycho-cardiological disease treated by Professor Zhao Haibin from January 2018 to April 2021 were recorded into the system of traditional Chinese medcine assisting inheritation platform(V2.5),and association rules and hierarchical clustering algorithms were adopted.Data mining was carried out from many aspects,such as drug frequency,four nature of drugs and five flavors,and their return meridian,core combination and potential new prescription.Results The 194 prescriptions contain 148 traditional Chinese medicine ingredients,warm,cold,and clam drugs were more common,while pungent,bitter,and sweet drugs were commonly used.The main channels were spleen,lung,stomach,liver,and heart.The top three Chinese medicines were Rhizoma Pinelliae,Poria,and Ramulus Cinnamomi.A total of 22 drug pairs combinations were obtained,and the correlation between Rhizoma Atractylodis Macrocephalae and Poria was the highest.Twenty-two core combinations composed of three drugs and four new formula combinations were excavated.Conclusion In the treatment of psycho-cardiological disease,Professor Zhao Haibin attaches great importance to regulating qi movement,and often uses the methods of regulating qi-flowing and heat-clearing,dissipating phlegm and inducing diuresis,supplementing qi and blood,promoting blood circulation for removing obstruction in collaterals,resolving phlegm and benefiting water,tonifying qi and blood,and tranquillization.