循环肿瘤细胞的检测方法

Methods for the detection of circulating tumor cells

循环肿瘤细胞(CTCs)携带着肿瘤发生、发展和转移的重要信息,与肿瘤转移密切相关。为了解CTCs的功能和分子特征以发展针对癌症有效地监测和治疗策略,发展CTCs富集和鉴定技术是关键环节。近年来,CTCs的体外检测技术取得了很大的进展,同时,具有实时、无创的体内检测技术也逐渐出现在市场。本文总结了目前CTCs的体内外检测方法,并提出了当前CTCs检测面临的挑战及策略。

Circulating tumor cells(CTCs)carry important information about tumor genesis,development,and metastasis and are closely associated with tumor metastasis.In order to understand the function and molecular characteristics of CTCs and develop effective surveillance and treatment strategies for cancer,the development of CTCs enrichment and identification technology is a key step.In recent years,great progress has been made in the detection of CTCs in vitro,at the same time,real-time,non-invasive in vivo detection technology has gradually emerged in the market.This paper summarizes the methods of CTCs detection in vitro and in vivo,and puts forward the challenges and strategies of CTCs detection.