涤痰化瘀汤对风痰入络证脑梗死急性期患者血清NO、ET水平的影响

Effect of Ditan Huayu Decoction on serum NO and ET levels in patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome

目的探讨涤痰化瘀汤对风痰入络证脑梗死急性期患者血清一氧化氮(NO)、内皮素(ET)水平的影响。方法选择2017年5月至2020年6月江苏省江阴市中医院收治的102例风痰入络证脑梗死急性期患者,根据随机数字表法将其分为对照组和研究组,各51例。对照组实施常规西药治疗,研究组在对照组治疗的基础上采用涤痰化瘀汤治疗,两组持续治疗4周。比较两组治疗前后风痰入络证中医症状评分、血清NO和ET水平,比较两组临床疗效及安全性。结果治疗前,两组风痰入络证中医症状评分、血清NO和ET水平比较,差异无统计学意义(P>0.05);治疗后,两组风痰入络证中医症状评分、血清NO水平均较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清ET水平较治疗前升高,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组临床总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论涤痰化瘀汤治疗风痰入络证脑梗死急性期患者的效果显著,可改善患者的血管内皮功能,且安全可靠。

Objective To investigate the effect of Ditan Huayu Decoction on serum nitric oxide(NO)and endothelin(ET)levels in patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome.Methods From May 2017 to June 2020,102 patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome in Jiangyin Hospital of Traditional Chinese Medicine in Jiangsu Province were selected and divided into control group and study group according to random number table method,with 51 cases in each group.Control group was treated with conventional Western medicine,and study group was treated with Ditan Huayu Decoction on the basis of the treatment of control group.Two groups continued treatment for four weeks.Traditional Chinese medicine symptom score,serum NO and ET levels of wind-phlegm invading collaterals syndrome were compared between two groups before and after treatment.Clinical efficacy and safety of two groups were compared.Results Before treatment,there was no significant difference in traditional Chinese medicine symptom score,serum NO and ET levels between two groups(P>0.05).After treatment,traditional Chinese medicine symptom score and serum NO level of wind-phlegm invading collaterals syndrome in two groups were lower than those before treatment,and study group was lower than that control group,the differences were statistically significant(P<0.05).After treatment,the levels of serum ET in two groups were higher than those before treatment,and study group was higher than that control group the differences were statistically significant(P<0.05).Total clinical effective rate of study group was higher than that of control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Ditan Huayu Decoction is effective in treating patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome.It can improve the vascular endothelial function of patients,and it is safe and reliable.