沉浸式虚拟现实训练对帕金森病轻度认知功能障碍患者认知功能的影响

Effects of immersive virtual reality training on cognitive function in Parkinson’s disease with mild cognitive impairment

目的:探讨沉浸式虚拟现实训练(VR)对帕金森病轻度认知功能障碍(PD-MCI)患者认知功能的影响。方法:选取PD-MCI患者32例,随机分为对照组16例和观察组各16例,2组均采用常规康复训练,对照组在常规康复训练基础上增加常规认知训练,观察组在常规康复治疗基础上增加VR治疗,分别于治疗前、治疗4周后采用蒙特利尔认知评估量表(MoCA)、连线测验(TMT)、连线测验(TMT)、画钟试验(CDT)、数字广度测验(DST)评估2组患者的认知功能。结果:治疗4周后,2组患者MoCA、CDT、DST-顺背和DST-倒背均较治疗前提高(均P<0.05),TMT-A和TMT-B均较治疗前降低(均P<0.05);且观察组MoCA、CDT、DST-顺背和DST-倒背均高于对照组(均P<0.05),TMT-A和TMT-B均低于对照组(均P<0.05)。结论:相较于常规认知训练,沉浸式VR对于改善PD-MCI患者认知功能可能更具优势。

Objective:To investigate of effects of immersive virtual reality(VR)training on cognitive function in Parkinson’s disease with mild cognitive impairment(PD-MCI).Method:A total of 32 cases of PD-MCI were selected in the Rehabilitation Department of Hangzhou Red Cross Hospital from November 2019 to May 2021,and randomly divided into the control group and the experimental group,16 cases each.Both groups received conventional rehabilitation training,and the control group was given conventional cognition training and the experimental group immersive VR training additionally.The Montreal cognitive assessment scale(MoCA),trail making test(TMT),clock drawing test(CDT)and the digit span task(DST)were used to evaluate the cognitive function of the two groups before and 4 weeks after treatment.Results:After 4 weeks of treatment,the MoCA score,CDT level,DST-forward and DST-backward levels in the two groups were improved compared to those before treatment,and levels of TMT-A and TMT-B were both lower than before treatment(P<0.05).Further comparison found that the MoCA score,CDT level,DST-forward and DST-backward levels in the experimental group were higher than those in the control group,and levels of TMT-A and TMT-B were lower than those in the control group after 4 weeks of treatment(P<0.05).Conclusion:Compared with conventional cognitive training,immersive VR training may be more advantageous for improving the cognitive function of PD-MCI patients.