不同剂量布托啡诺对白犀牛镇静的药效学比较

Pharmacodynamic Comparison of Different Doses of Butorphanol on White Rhinoceros

本试验使用4种不同剂量[5~20μg/(kg·bw)]的布托啡诺对雌性白犀牛进行镇静,对不同时间进行的各种临床诊断和治疗过程中的生理参数进行监测和记录。镇静后可以进行一系列的操作,如X线、超声波、内窥镜检查、采血和输液。在局麻的配合下,进行第3眼睑缝合结扎、角基外科螺钉植入等手术治疗。结果表明布托啡诺镇静止痛效果好,副作用少,拮抗剂(纳洛酮)可安全快速的使动物恢复,可满足白犀牛临床诊断和治疗的需要。本试验是国内首次使用布托啡诺镇静白犀牛的报道。

This study utilized four different doses [5-20 μg/(kg·bw)] of butorphanol to sedate a female white rhinoceros, for a variety of clinical diagnostic and treatment procedures at different time frames. The physiological parameters during sedation were monitored and recorded. The sedation allowed a series of operations, such as X-ray, ultrasound, endoscopy, blood collection and infusion. In combination with local anesthesia, surgical operations such as suture and ligation of the third eyelid and orthopedic screw insertion to repair the broken horn were performed. Butorphanol which has good sedate and analgesic effect and fewer side effects and animal can recover safely and quickly with antagonize(naloxone), which can meet the needs of clinical diagnostics and treatment of white rhinoceros. This study is the first report of butorphanol used to sedate white rhinoceros.