叶天士治疗疑似肝癌验案的用药规律分析

Analysis of Medication Rule of Ye Tian-shi in Treating Suspected Liver Cancer

目的基于数据挖掘技术分析和总结叶天士治疗疑似肝癌病的用药特点和组方规律。方法查阅《叶天士医学全书》中治疗疑似肝癌验案中有效中药组方,建立中药数据库,进行标准化处理,应用古今医案云平台对药物进行频次统计、聚类分析、复杂网络分析等研究。结果本研究纳入有效处方64首,涉及中药129味。其中高频药物为当归、茯苓、川楝子、桃仁、小茴香、香附等;中药四气以温为主,平、寒次之;中药五味以辛为主,苦、甘次之;中药归经主要归脾经,其次为肝、心二经;关联规则得到22条药物组合,聚类分析共得到8类药物;核心处方是以金铃子散和暖肝煎为基础方加减。结论叶天士治疗疑似肝癌病以温阳扶正、化痰逐瘀为主要治法,可为肝癌中医药临床治疗提供一定的借鉴。

OBJECTIVE To analyze and summarize the drug characteristics and prescription rule of Ye Tian-shi in the treatment of suspected liver cancer based on data mining technology.METHODS Refer to Ye Tian-shi Medical Complete Book of effective TCM prescriptions in the treatment of suspected liver cancer,establish TCM database,conduct standardized treatment,and use ancient and modern medical case cloud platform to conduct frequency statistics,cluster analysis,complex network analysis,etc.RESULTS The 64 effective prescriptions were included in this study,involving 129 Chinese medicine,such as Angelicae Sinensis Radix,Poria,Toosendan Fructus,Persicae Semen,Foeniculi Fructus,Cyperi Rhizoma,etc,had high frequency.The four Qi of traditional Chinese medicine was mainly warm,followed by flat and cold;the five flavors of traditional Chinese medicine were mainly pungent,followed by bitter and sweet;the channel tropism of traditional Chinese medicine were mainly spleen meridians,followed by liver and heart meridians;22 drug combinations were obtained by association rules,and a total of 8 drug categories were obtained by cluster analysis.The core prescriptions were addition and subtraction based on Jinlingzi powder and Nuangan decoction.CONCLUSION Ye Tian-shi’s treatment for suspected hepatocellular carcinoma is mainly treated by warming Yang and strengthening the body,eliminating phlegm and removing blood stasis,which provides a certain reference for the clinical treatment of hepatocellular carcinoma with traditional Chinese medicine.