雾化吸入3%高渗盐水在中度毛细支气管炎患儿中的应用效果

Application effect of nebulized inhalation of 3% Hypertonic Saline in children with moderate bronchiolitis

目的探讨雾化吸入3%高渗盐水(HS)在中度毛细支气管炎患儿中的应用效果。方法选取2018年7月至2020年10月在南宁市武鸣区妇幼保健院儿科住院治疗的72例中度毛细支气管炎患儿作为研究对象,采用随机数字表法将其分为3%HS组和生理盐水(NS)组,各36例。3%HS组采用3%HS 2 ml,NS组采用NS 2 ml,雾化吸入。比较两组患儿治疗前、治疗后24、48、72 h、出院时的临床严重度评分(CSS)及住院时间,观察不良反应。结果两组患儿治疗后24、48、72 h、出院时CSS比较,差异无统计学意义(P>0.05)。3%HS组患儿治疗前、治疗后24、48、72 h、出院时CSS均随时间递推显著降低,前后时点间CSS比较,差异有统计学意义(P<0.05)。NS组患儿治疗前、治疗后24、48、72 h、出院时CSS均随时间递推显著降低,前后时点间CSS比较,差异有统计学意义(P<0.05)。两组患儿住院时间比较,差异无统计学意义(P>0.05)。两组患儿均未发现不良反应。结论与NS比较,3%HS联合布地奈德、沙丁胺醇、异丙托溴铵雾化吸入治疗中度毛细支气管炎,未显著降低CSS和缩短住院时间,需单用HS进一步研究。

Objective To examine the application effect of atomizing inhalation of 3% Hypertonic Saline(HS)in children with moderate bronchiolitis.Methods A total of 72 children with moderate bronchiolitis who were hospitalized in the Department of Pediatrics of Maternal and Child Health Centre of Wuming District from July 2018 to October 2020 were selected as research objects.They were divided into 3% HS group and noral saline(NS)group according to random number table method,with 36 cases in each group.3% HS 2 ml was used in 3% HS group and NS 2 ml was used in NS group.The clinical severity scores(CSS)and length of hospital stay in the pre-treatment phase,24,48,72 h after treatment and at discharge of two groups were compared,and the adverse effect were observed.Results There were no significant differences in CSS between two groups at 24,48,72 h after treatment and at discharge(P>0.05).The CSS in the pre-treatment phase 24,48,72 h after treatment and at discharge were significantly decreased over time in 3% HS group,the differences were statistically significant(P<0.05).The CSS in the pre-treatment phase,24,48,72 h after treatment and at discharge were significantly decreased over time in NS group,the differences were statistically significant(P<0.05).There was no significant difference in length of hospital stay between groups(P>0.05).No adverse reaction occured in both groups.Conclusion Compared with NS,3% HS combined with Budesonide,Salbutamol and Ipratropium Bromide Atomized Inhalation in the treatment of moderate bronchiolitis did not significantly reduce the CSS and shorten the length of hospital stay,requiring further study with HS alone.