热敏灸联合阿片类药物治疗虚型癌痛增效作用研究

Study on the Synergistic Effect of Thermal Moxibustion Combined with Opioids in the Treatment of Deficiency Cancer Pain

目的 观察研究热敏灸联合阿片类药物治疗虚型癌痛增效作用。方法 选取40例中、重度虚型癌痛患者为对象,采用随机对照试验方法分为2组,对照组使用阿片类代表性药物盐酸羟考酮控释片,治疗组在对照组基础上联合中医热敏灸疗法,热敏灸治疗1次/d;21 d为一个周期,周期间隔2 d,共治疗2个周期。观察比较2组患者治疗后疼痛程度及生活质量变化。结果 2组患者治疗后疼痛缓解程度比较,其中对照组总有效率75.0%。治疗组总有效率85.0%,2组比较,P <0.01,差异具有显著统计学意义。2组患者治疗后生活质量改善程度比较,对照组总有效率85.0%,治疗组总有效率90.0%,2组比较,P <0.01,差异具有显著统计学意义。结论 热敏灸联合阿片类药物治疗虚型癌痛优于单纯西药治疗癌痛,能够明显改善癌痛患者的疼痛和生活质量,临床疗效确切,值得临床进一步应用推广。

Objective To observe the synergistic effect of thermal moxibustion combined with opioids in the treatment of deficiency cancer pain.Methods 40 patients with moderate and severe deficiency cancer pain were selected and randomly divided into two groups.The control group was treated with oxycodone hydrochloride controlled-release tablets,a representative opioid drug.The treatment group was treated with traditional Chinese medicine thermal moxibustion once a day on the basis of the control group.21 days was a cycle,the interval was 2 days,a total of 2 cycles.Then the pain degree and quality of life of the two groups were observed and compared.Results The pain relief degree of the two groups was compared,and the effective rate of the control group was 75.0%.The effective rate of the treatment group( thermal moxibustion group) was 85.0%.The difference between the two groups was statistically significant( P <0.01).The effective rate of the control group was 85.0%,the effective rate of the treatment group( thermal moxibustion group) was 90.0%,and the difference between the two groups was statistically significant( P < 0.01).Conclusion Thermal moxibustion combined with opioids in the treatment of deficiency cancer pain is better than that of western medicine alone.It can significantly improve the pain and quality of life of patients with cancer pain,and the clinical curative effect is exact,which is worthy of further clinical application and promotion.