双负载抗生素亲水性聚氨酯泡沫的制备与表征

Preparation and characterization of dual-antibiotic-loaded hydrophilic polyurethane foam

因细菌、异物和炎症等因素引起的慢性伤口会有过量的伤口渗出液流出,影响伤口周围健康皮肤,不利于伤口愈合。针对以上问题,我们开发了双负载亲、疏水性抗生素的亲水性聚氨酯泡沫作为慢性伤口的创面敷料。通过电子显微镜观察,泡沫的孔径均匀地分布在200~400μm之间。聚氨酯泡沫中载入的药物对聚氨酯泡沫的力学性能略有影响,对吸液率、保水率没有影响,载入的亲水性药物能够快速释放,疏水性药物能够持续释放。载药聚氨酯泡沫对革兰氏阴性菌大肠杆菌和革兰氏阳性菌金黄色葡萄球菌均表现出优异的抗菌性能。同时,载药聚氨酯泡沫具有优异的生物相容性。因此,这种多功能聚氨酯泡沫适合作为慢性伤口敷料的候选材料。

Chronic wounds caused by bacteria,foreign bodies,inflammation and other factors will have excessive wound exudate outflow,damaging the surrounding healthy skin,which is not conducive to wound healing.To solve the above problems,we prepared polyurethane foam containing hydrophilic and hydrophobic drugs as a wound dressing for chronic wounds.The pore size of the foam was uniform and distributed between 200—400μm observed by SEM.The loading drugs had a slight effect on the mechanical properties of polyurethane foam and had little effect on the liquid absorption rate and water retention rate.The hydrophilic drug could be released rapidly,and hydrophobic drug could be released continuously.The drug-loaded polyurethane foam showed excellent antibacterial activity against gram-negative E.coli and gram-positive S.aureus.Meanwhile,polyurethane foams had excellent biocompatibility.Therefore,the multifunctional polyurethane foams are suitable as a candidate material for chronic wound dressing.