淋巴瘤中医证型与预后因素相关性研究

Preliminary study on the correlation between TCM syndrome types and prognostic factors of lymphoma

目的 探究淋巴瘤中医证型分布及证型与预后因素的相关性。方法 收集2019年7月1日至2021年2月1日南开大学人民医院就诊的淋巴瘤患者,应用SPSS 26.0软件将收集到的证型进行频次分析,并分析中医证型与患者性别、年龄、BMI、淋巴瘤病理类型、临床分期、疾病病程、治疗阶段、Ki-67、β2-MG、LDH及B症状的相关性。结果 154例患者完成入组,常见证型为瘀血内阻证、痰湿凝结证、虚实夹杂证等;与热毒内结证相比,瘀血内阻证与BMI、Ki-67、男性,痰瘀互结证与病程、病理类型,气血两虚证与BMI、Ki-67,痰湿凝结证与病理类型有较强的关联性。结论 淋巴瘤类型以弥漫大B细胞淋巴瘤、滤泡淋巴瘤、霍奇金淋巴瘤为主,且以复发/难治的中老年患者居多,常见瘀血内阻证、痰湿凝结证等证型;性别、BMI、Ki-67、病理类型、病程等客观指标有望成为淋巴瘤中医辨证分型的辅助指标。

Objective To explore the distribution of TCM syndrome types of lymphoma and the correlation between syndrome types and prognostic factors.Methods The patients with lymphoma treated in People’s Hospital of Nankai University from July 1,2019 to February 1,2021 were collected.The frequency of the collected syndrome types were analyzed by SPSS 26.0software.The relationship between TCM syndrome types and patients’ gender,age,BMI,lymphoma pathological type,clinical stage,disease course,treatment stage,Ki-67,β2-MG,LDH and B symptoms was analyzed.Results 154 patients were enrolled.The common syndrome types were blood stasis internal obstruction syndrome,phlegm dampness congealing syndrome,deficiency and excess mixed syndrome;compared with heat toxin syndrome,blood stasis internal obstruction syndrome with BMI,Ki-67,male,phlegm and blood stasis syndrome with course of disease,pathological type,Qi and blood deficiency syndrome with BMI,Ki-67,phlegm dampness coagulation syndrome with pathological type had strong correlation.Conclusion The main types of lymphoma are diffuse large B cell lymphoma,follicular lymphoma and hodgkin lymphoma,and most of them are relapsed or refractory in middle-aged and elderly patients;gender,BMI,Ki-67,pathological type,course of disease and other objective indicators are expected to become auxiliary indicators of TCM syndrome differentiation of lymphoma.