伊托必利、莫沙必利分别联合氟哌噻吨美利曲辛治疗功能性消化不良的效果及安全性

Efficacy and Safety of Itopride or Mosapride Combined with Flupentixol and Melitracen in the Treatment of Functional Dyspepsia

目的:探究伊托必利、莫沙必利分别联合氟哌噻吨美利曲辛治疗功能性消化不良的效果及安全性。方法:将赣南医学院第三附属医院2018年5月至2021年6月收治的82例功能性消化不良患者作为研究对象,按抽签法分为观察组和对照组,每组各41例,对照组给予莫沙必利联合氟哌噻吨美利曲辛治疗,观察组采用伊托必利联合氟哌噻吨美利曲辛治疗,治疗2周后对比两组患者临床疗效、症状评分、不良反应、胃蛋白酶原及胃泌素指标等。结果:观察组临床总有效率与对照组差异无统计学意义(P>0.05);两组治疗前后饱胀、上腹痛、灼烧感各症状评分相比,差异无统计学意义(P>0.05),但同组治疗后饱胀、上腹痛、灼烧感各症状评分明显低于治疗前(P<0.05);两组治疗前后胃蛋白酶原(PG)及胃泌素-17(G-17)各指标相比,差异无统计学意义(P>0.05),但同组治疗后PG、G-17各指标明显高于治疗前(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论:伊托必利、莫沙必利分别联合氟哌噻吨美利曲辛治疗功能性消化不良均能明显提高临床疗效,减低症状评分,能较好地调节胃动力作用,患者可根据经济情况选择药物。

Objective:To explore the efficacy and safety of itopride or mosapride combined with flupentixol and melitracen in the treatment of functional dyspepsia.Methods:82 patients with functional dyspepsia treated in The Third Affiliated Hospital of Gannan Medical University between May 2018 and June 2021 were enrolled as the research subjects,and they were divided into observation group and control group according to the lottery method,with 41 cases in each group.The control group was given mosapride combined with flupentixol and melitracen,and the observation group was treated with itopride combined with flupentixol and melitracen.After 2 weeks of treatment,the clinical efficacy,symptom scores,adverse reactions,pepsin and gastrin indexes of the two groups were compared.Results:The total clinical effective rate of observation group was higher than that of control group (P>0.05).There were no statistical differences in the scores of symptoms of fullness,epigastric pain and burning sensation between the two groups before and after treatment (P>0.05),but the scores of symptoms after treatment in the same group were significantly lower than those before treatment (P<0.05).The indexes of pepsin (PG) and gastrin-17 (G-17) were not statistically significant before and after treatment (P>0.05),but the levels of PG and G-17 after treatment in the same group were significantly higher than those before treatment (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Both itopride and mosapride combined with flupentixol and melitracen in the treatment of functional dyspepsia can significantly improve the clinical efficacy,reduce the symptoms scores,and play a good role in regulating the gastric dynamics.It is necessary for patients to select the drug according to the economic situation of patients.