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Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor 被引量:1

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摘要 Orally absorbable gold nanoparticles(AuNP)having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme(GBM)for patients with its highest incidence rate.Here,we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin(Lf)and lactoferrin receptor(LfR)that is highly expressed in the intestine,blood-brain barrier and GBM.For stability and long circulation of AuNP,glutathione and polyethylene glycol(PEG)is introduced,which is called to Lf-PEG-AuNP.When Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice,11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain,respectively,compared with unconjugated-AuNP.Therefore,orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor volume.Collectively,we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption,and that its efficient photothermal therapy is possible.
出处 《Bioactive Materials》 SCIE 2022年第2期35-48,共14页 生物活性材料(英文)
基金 supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT&Future Planning(NRF-2020R1A2C3005834).
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