链球菌-韦荣菌共生对系统性疾病的诊断价值研究

Diagnostic value of the symbiosis of Streptococcus and Veillonella in systemic diseases

口腔是人体生理功能的窗口,也是种类和数量繁多的微生物库。口腔微生态变化能够反映宿主与环境因素的相互作用,进而影响机体健康和疾病的进展。其中,链球菌属(Streptococcus)和韦荣菌属(Veillonella)是口腔最早的定殖菌和典型共生菌,共同参与口腔早期生物膜形成。大量研究显示,链球菌和韦荣菌共生失调不仅与龋病、牙周病等口腔疾病密切相关,而且可突破或入侵消化屏障实现远端定殖,已经成为预测多种系统性疾病发生、发展及预后的新的潜在生物标志物。本文综述链球菌-韦荣菌在口腔的共生致病机制,分析其在系统性疾病相关微生态研究中的变化特征,提出具有代表性的共生菌诊断组合,以期为系统性疾病的诊断和防治提供科学依据。

Nurturing numerous microorganisms,oral cavity is the window into the physiological functions of the body.Oral microbiota is a mirror of the interaction between the host and environmental factors,which influences human health and disease progress.As the early colonizers of the oral cavity,the symbiotic Streptococcus and Veillonella contribute to the development of biofilm in human oral cavity.Mounting evidence suggests the key role of the symbiont in the development of many oral disorders,such as dental caries and periodontal disease.In certain state,they can also break through or invade the digestive barrier to colonize in remote organs,thereby affecting human health.They have been used as potential biomarkers for the occurrence,development,and prognosis of many systemic diseases.Thus,this paper reviewed the pathogenic mechanism of the Streptococcus–Veillonella symbiont,analyzed the characteristics of them in the microecosystem related to common systemic diseases,and proposed the representative diagnostic combinations,which would be expected to lay a scientific basis for the diagnosis and prevention of systemic diseases.