海昆肾喜胶囊联合贝那普利对慢性肾功能衰竭患者TGF–β1、CTGF的影响

Effect of Haikunshenxi Capsule Combined with Benazepril on TGF-β1 and CTGF in the Treatment of Chronic Renal Failure

目的:探讨海昆肾喜胶囊联合贝那普利治疗慢性肾功能衰竭(CRF)患者的疗效及对血清转化生长因子β1(TGF–β1)、结缔组织生长因子(CTGF)的影响。方法:收集巩义市人民医院2016年8月至2018年7月期间收治的CRF患者120例,采用抽签分组法将其分为观察组和对照组,每组60例。对照组给予贝那普利治疗,观察组在对照组基础上加海昆肾喜胶囊治疗。比较两组的临床疗效、治疗前后TGF–β1、CTGF水平及肾功能指标(血清肌酐、尿素氮),并观察治疗期间不良反应发生情况。结果:观察组患者治疗总有效率为86.7 %,高于对照组的63.3 %,差异具有统计学意义(P<0.05)。治疗后,两组患者血清肌酐、尿素氮水平均较治疗前下降,且观察组明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者血清TGF–β1、CTGF水平均较治疗前下降,且观察组明显低于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:与单纯贝那普利治疗相比,海昆肾喜胶囊联合贝那普利治疗CRF可获得更好的疗效,降低TGF–β1、CTGF的表达,从而改善肾纤维化,延缓疾病进展。

Objective To investigate the effect of Haikun Shenxi capsule combined with benazepril on transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) in the treatment of chronic renal failure(CRF).Methods A total of 120 patients with CRF admitted to Gongyi City People’s Hospital from August 2016 to July 2018 were divided into observation group and control group by drawing lots,with 60 cases in each group.The control group was treated with benazepril,and the observation group was treated with Haikunshenxi capsule on the basis of the control group.The clinical efficacy,TGF-β1,CTGF levels and renal function indexes (serum creatinine,urea nitrogen) before and after treatment were compared between the two groups,and the incidence of adverse reactions during treatment were observed.Results The total effective rate of observation group was 86.7%,which was higher than 63.3% of the control group,and the difference was statistically significant (P < 0.05).After treatment,serum creatinine and urea nitrogen levels in the two groups were decreased compared with before treatment,and the observation group was significantly lower than that in the control group,the differences were statistically significant (P < 0.05).After treatment,the levels of serum TGF-β1 and CTGF in the two groups were decreased compared with before treatment,the observation group was significantly lower than taht in the control group,the differences were statistically significant (P < 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05).Conclusion Compared with benazepril alone,Haikunshenxi capsule combined with benazepril in the treatment of CRF can achieve better efficacy,reduce the expression of TGF-β1and CTGF,thereby improving renal fibrosis and delaying disease progression.