哺乳动物卵母细胞成熟及早期胚胎发育中组蛋白修饰研究进展

Advances in Histone Modification of Mammalian Oocytes and Early Embryos Development

在动物生产中,卵母细胞及早期胚胎的发育质量是影响动物繁殖性能的关键因素。哺乳动物卵母细胞成熟及早期胚胎发育过程中存在活跃的组蛋白修饰变化,其中对组蛋白甲基化和乙酰化研究最多,活跃的组蛋白修饰变化在细胞重编程过程中起到重要的调控作用。本文综述了哺乳动物卵母细胞及受精后早期胚胎的组蛋白甲基化和乙酰化动态修饰变化以及影响因素,为哺乳动物的发育研究提供理论依据。

The developmental quality of oocytes and early embryos in animal production is a key factor affecting the reproductive performance of animals.Studies have shown that there are active histone modification changes during mammalian oocyte maturation and early embryo development,among which histone methylation and acetylation are the most studied,and the active histone modification changes play an important regulatory role in the cellular reprogramming process.This paper mainly reviews the dynamic modification changes of histone methylation and acetylation in mammalian oocytes and early embryos after fertilization and the factors affecting them,aiming to provide a theoretical basis for developmental studies in mammals.