程为平教授辨治抽动秽语综合征用药规律分析

Analysis of the medication rule of Professor Cheng Weiping in the treatment of Gilles de la Tourette syndrome

目的归纳总结程为平教授临床治疗抽动秽语综合征的组方及用药规律。方法提取2018年1月至2021年6月黑龙江中医药大学程为平教授门诊电子病历数据,筛选、处理相关病历并录入中医传承辅助平台(V3.0),采用频数分析、聚类分析、关联规则等统计方法,总结核心药物,归纳辨治规律。结果共纳入方剂94首,涉及101味中药。四气以性平药和温性药为主;五味以甘味药和苦味药为主;归经以肺经和心经为主。使用频次≥30次的药物有炙龟板、天麻、生地黄、炙甘草等14味;使用频次最多的药物为补虚药。频次≥45次的高频药物组合有19组;置信度≥0.8的常用药物组合共有33对。根据药物聚类分析结果得到4类核心药物组合。结论程教授治疗抽动秽语综合征主要以补肾填精益髓,平肝息风,疏肝柔肝为主。

Objective To summarize the prescription and medication rule of Professor Cheng Weiping in the treatment of Gilles de la Tourette syndrome.Methods The electronic medical record data of the outpatient Department of Professor Cheng Weiping of Heilongjiang University of Chinese Medicine from January 2018 to June 2021 were extracted,relevant medical records were screened and processed,and were input into the traditional Chinese medicine inheritance assistance platform(V3.0).Statistical methods such as frequency analysis,cluster analysis,and association rules were used to summarize the core drugs and summarize the rules of differentiation and treatment.Results A total of 94 prescriptions involving 101 Chinese medicines were included.The four nature of drugs were mainly composed of plain medicine and warm medicine.The five flavours were mainly sweet taste and bitter taste.The main channels were lung channel and heart channel.The drugs with the frequency≥30 times included 14 herbs,such as prepared stir-frying with tortoise plastron,Gastrodiae Rhizoma,Rehmanniae Radix,and Glycurrhizae Radix Et Rhizoma Praeparata Cum Melle.The most frequently used drugs were tonify deficiency medicine.There were 19 groups of high frequency drug combinations with frequency≥45 times;there were 33 pairs of commonly used drug combinations with confidence level≥0.8.Four types of core drug combinations were obtained according to the results of drug cluster analysis.Conclusion Professor Cheng’s treatment of Gilles de la Tourette syndrome mainly focuses on tonifying kidney and tonifying and replenishing marrow and essence,suppressing hyperactive liver for calming endogenous wind,dispersing stagnated liver qi and softening liver.