适度摄入锰有益于心血管健康:基于美国NHANES 2011—2018年数据

Moderate intake of manganese benefits cardiovascular health:Based on NHANES 2011—2018

目的探讨血锰浓度与成年人心血管疾病患病率及独立不良心血管事件发生率的关联。方法整合美国国家健康和营养调查(national health and nutrition examination survey,NHANES)2011―2018年数据,根据入排标准纳入4005名20至60岁成年人。通过构建广义线性模型及限制性三次样条曲线来分析血锰浓度和心血管疾病患病率之间的关联。通过多因素logistic回归分析探索独立不良心血管事件发生与血锰浓度的关系。结果与最低四分位数(Q1)相比,血锰浓度四分位数中(Q2,Q3,Q4)心血管疾病发生率的校正优势比(可信区间)分别为1.066(0.699~1.699),1.105(0.639~1.613)和0.591(0.376~0.930)。在完全调整模型中,血锰浓度与心血管疾病患病率呈先下降后上升关系。限制性三次样条曲线表明血锰浓度与心血管疾病患病率呈“U”型相关关系。不良心血管独立事件与血锰的关联和总体心血管疾病患病率一致。结论基于成年人,血锰浓度与心血管疾病患病率相关,随着血锰浓度上升,心血管疾病发生率呈先降后升的趋势,维持血锰浓度在9.59μg/L对心血管疾病患病率和独立不良事件有益。

Objective:To explore the relationship between blood manganese concentration and the incidence of cardiovascular diseases(CVDs)as well as individual CVDs in adults.Methods:We initially integrated the data in National Health and Nutrition Examination Survey(NHANES)from 2011 to 2018.4005 adults agd between 20 and 60years old were recruited based on the inclusion and exclusion criteria.The relationship between manganese concentration and the prevalence of CVD was analyzed by constructing generalized linear models and restricted cubic spline curves.Results:Compared with the lowest quartile,the modified odds ratios(ORs)with 95%confidence intervals(CIs)for CVD prevalence across the manganese quartiles were 1.066(0.699,1.699),1.105(0.639,1.613),and 0.591(0.376,0.930)respectively.In the full adjusted model,the incidence of total CVD decreased initially and increased when manganese concentration was over 9.59μg/L.A restricted cubic spline curve was used to show a nonlinear“U”shape relationship between manganese concentration and CVD.Conclusion:Based on adults,blood manganese concentration was associated with CVD prevalence.Maintaining manganese concentration at 9.59μg/L can be beneficial for the heart.