鼠神经生长因子对原发性闭角型青光眼术后视神经保护作用研究

Research on protective effect of rat nerve growth factor on the optic nerve after primary angle closure glaucoma

目的探讨鼠神经生长因子(RNGF)对原发性闭角型青光眼(PACG)患者术后视神经的保护作用。方法选取2019—2020年间我院收治的36例PACG小梁切除术患者为研究对象,按照随机抽签法将其分为对照组和观察组。观察组术后采用甲钴胺,对照组采用RNGF,均连续治疗30d。比较两组治疗前后视功能指标和NO、ET-1、NSE水平。结果与治疗前相比,两组眼压、平均光敏度、平均缺损在治疗后均有所改善,且观察组平均光敏度较高平均缺损值较低(P<0.05);治疗后两组NO提升,ET-1、NSE下降,且观察组NO明显较高,ET-1、NSE较低(P<0.05)。结论RNGF对PACG术后患者不仅能改善患者视力,也有利于视神经功能的恢复。

Objective To investigate the protective effect of rat nerve growth factor on the optic nerve after primary angle closure glaucoma(PACG).Methods 36 patients with PACG trabeculectomy in our hospital from 2019 to 2020 were selected and were divided into control and observation groups according to random lottery.The observation group was followed by postoperative methocobalamin and murine nerve growth factor in the control group,all treated continuously for 30d.The visual functional indicators and NO,ET-1,and NSE levels were compared between the two groups.Results Compared with that before treatment,intraocular P,mean photoacuity and mean defect in both groups improved after treatment,with high mean optical sensitivity and low mean defect value(P<0.05).After treatment,NO increased,ET-1 and NSE decreased,significantly higher NO,lower ET-1 and NSE(P<0.05).Conclusion Rat nerve growth factor can not only improve patient vision,but also facilitate the recovery of optic nerve function.