探究介入治疗中晚期原发性肝癌患者的临床疗效及对肝功能的影响

Exploration of effect of interventional therapy on clinical efficacy and liver function of patients with advanced primary liver cancer

目的探究介入治疗中晚期原发性肝癌患者的临床疗效及对肝功能的影响。方法选取2017年1月至2019年1月本院收治的中晚期原发性肝癌患者100例作为研究对象,按照治疗方法不同分为载药微球组和碘化油组,每组50例。载药微球组采用载药微球治疗,碘化油组采用碘化油治疗。比较两组临床症状评分、生活质量评分量表(QOL)评分、肝功能、临床疗效及不良反应发生率、1年生存率、总生存期(OS)。结果治疗后,两组疼痛评分、乏力评分、腹胀评分均低于治疗前,QOL评分均高于治疗前,且载药微球组疼痛评分、乏力评分、腹胀评分均低于碘化油组,QOL评分高于碘化油组(P<0.05)。治疗后,两组清蛋白(ALB)均高于治疗前,总胆红素(TBIL)、谷丙转氨酶(ALT)均低于治疗前,且载药微球组ALB高于碘化油组,TBIL、ALT均低于碘化油组(P<0.05)。载药微球组治疗总有效率为84.0%,高于碘化油组的64.0%,差异有统计学意义(P<0.05)。载药微球组恶心呕吐、发热、白细胞降低、脱发发生率均低于碘化油组,差异有统计学意义(P<0.05),两组感染发生率比较差异无统计学意义。载药微球组1年生存率为88.0%,高于碘化油组的66.0%,OS显著长于碘化油组,差异有统计学意义(P<0.05)。结论中晚期原发性肝癌患者介入治疗临床疗效优于传统经导管肝动脉化疗栓塞,能有效改善患者的肝功能,降低疼痛评分及不良反应发生率,延长生存期,值得临床推广应用。

Objective To explore the effect of interventional therapy on clinical efficacy and liver function of patients with advanced primary liv-er cancer.Methods 100 patients with advanced primary liver cancer treated in our hospital from January 2017 to January 2019 were selected as the research subjects,and they were divided into drug loaded microspheres group and iodized oil group according to different treatment methods,with 50 cases in each group.The drug loaded microspheres group was treated with drug loaded microspheres,and the iodized oil group was treated with io-dized oil.The clinical symptom score,quality of life(QOL)score,liver function,clinical efficacy,adverse reactions rates,1-year survival rates and overall survival(OS)were compared between the two groups.Results After treatment,the pain score,fatigue score and abdominal distension score of the two groups were lower than those before treatment,and the QOL score was higher than that before treatment,the pain score,fatigue score and abdominal distension score of the drug loaded microspheres group were lower than those of the iodized oil group,and the QOL score was higher than that of the iodized oil group(P<0.05).After treatment,albumin(ALB)in both groups was higher than that before treatment,total bilirubin(TBIL)and alanine aminotransferase(ALT)were lower than that before treatment,ALB in drug loaded microspheres group was higher than that in iodized oil group,and TBIL and ALT were lower than that in iodized oil group(P<0.05).The total effective rate of drug loaded microspheres group was 84.0%,which was higher than 64.0%in iodized oil group(P<0.05).The incidence of nausea,vomiting,fever,leucopenia and hair loss in the drug loaded microspheres group were lower than those in the iodized oil group,the difference was statistically significant(P<0.05),and there was no sig-nificant difference in the incidence of infection between the two groups.The 1-year survival rate of drug loaded microspheres group was 88.0%,which was higher than 66.0%in iodized oil group,OS was significantly longer than that in iodized oil group(P<0.05).Conclusion The clinical efficacy of interventional therapy in patients with advanced primary liver cancer is better than that of traditional transcatheter arterial chemoemboli-zation,it can effectively improve the liver function,reduce the pain score,reduce the incidence of adverse reactions and prolong the survival time,it is worthy of clinical application.