放射治疗联合干扰素治疗艾滋病相关型卡波西肉瘤的疗效及近期预后研究

Curative effect and short-term prognosis of radiotherapy combined with interferon in treating AIDS-related Kaposi’s sarcoma

目的:研究放射治疗联合干扰素治疗艾滋病相关型卡波西肉瘤的疗效及近期预后。方法:选取医院收治的102例艾滋病相关型卡波西肉瘤患者临床资料,按照治疗方法的不同将其分为对照组(45例)和观察组(57例)。对照组仅给予放射治疗,观察组给予放射治疗联合干扰素免疫治疗,对比两组临床疗效、不良反应、随访1年的生存率及死亡患者的中位生存期。结果:观察组临床总有效率为96.49%,高于对照组(82.22%),两组比较差异有统计学意义(χ^(2)=4.289,P<0.05);两组不良反应发生率比较差异无统计学意义。观察组和对照组随访1年生存率分别为98.25%和84.44%,两组比较差异有统计学意义(χ^(2)=4.855,P<0.05),死亡患者的中位生存期观察组长于对照组,两组比较差异有统计学意义(t=11.792,P<0.05)。结论:放射治疗联合干扰素治疗艾滋病相关型卡波西肉瘤可促进缓解及改善相关临床症状及体征,未增加不良反应,随访1年生存率较高,死亡患者中位生存期较长,近期预后整体较好。

Objective:To explore and analyze the curative effect and short-term prognosis of radiotherapy combined with interferon in treating acquired immune deficiency syndrome(AIDS)-related Kaposi’s sarcoma.Methods:The clinical data of 102 patients with AIDS-related Kaposi’s sarcoma admitted to hospital were selected and they were divided into control group(45 cases)and observation group(57 cases)according to different treatment methods.The control group received only radiotherapy,and the observation group received radiotherapy combined with interferon immunotherapy.The clinical efficacy,adverse reactions,survival rate and median survival time of died patients within follow-up 1 year were compared between the two groups.Results:The total clinical effective rate of observation group was 96.49%,which was significantly higher than that of control group,and the difference of that between two groups was statistically significant(χ^(2)=4.289,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.The survival rate of follow-up 1 year of observation group was significantly higher than that of control group(χ^(2)=4.855,P<0.05),and the median survival time of died patients of observation group was significantly longer than that of control group(t=11.792,P<0.05).Conclusion:The treatment of radiotherapy combined with interferon can promote the relief and improvement of related clinical symptoms and signs of AIDSrelated Kaposi’s sarcoma,and doesn’t increase the adverse reaction.The survival rate of follow-up 1 year of that is higher,and the median survival time of died patients is longer.In addition,the short-term prognosis of that is overall better.