尿酸、糖化血红蛋白与甲状腺结节发病的关系研究

Study on the Relationship Between the Levels of Uric Acid and Glycosylated Hemoglobin and the Pathogenesis of Thyroid Nodules

目的探讨尿酸(UA)与糖化血红蛋白(HbAlc)水平与甲状腺结节发病的关系。方法选取2017年1月至2020年1月于我院体检中心体检者1200例为研究对象,均行甲状腺超声检查,并收集受检者一般资料和实验室指标。分析甲状腺结节患病率,对比有结节组与无结节组年龄、体重指数(BMI)、HbAlc、UA、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等指标差异,分析影响甲状腺结节发病的相关危险因素。结果1200名受检人员中,甲状腺结节总患病率为14.67%(176/1200),女性甲状腺结节患病率高于男性,差异有统计学意义(P<0.05);有结节组年龄、BMI、HbAlc、UA、FBG、TC、TG、LDL-C明显高于无结节组,HDL-C低于无结节组,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,年龄、UA、性别、HbAlc是甲状腺结节发病的高危因素(P<0.05且OR>1)。结论年龄、UA、性别、HbAlc是甲状腺结节发病的高危因素,针对此类人群需加强甲状腺超声检查,以早期发现甲状腺结节,尽早实施治疗。

Objective To investigate the relationship between uric acid(UA)and glycosylated hemoglobin(HbAlc)levels and the incidence of thyroid nodules.Methods A total of 1,200 patients who were examined in our hospital’s physical examination center from January 2017 to January 2020 were selected as the research subjects.All of them underwent thyroid ultrasound examination,and collected general information and laboratory indicators of the subjects.Analyze the prevalence of thyroid nodules,compare age,body mass index(BMI),HbAlc,UA,fasting blood glucose(FBG),total cholesterol(TC),triacylglycerol(TG),low Differences in indicators such as density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),etc.,to analyze related risk factors affecting the onset of thyroid nodules.Results Among 1200 subjects,the total prevalence rate of thyroid nodules was 14.67%(176/1200).The prevalence rate of thyroid nodules in women was higher than that in men,and the difference was statistically significant(P<0.05);group with nodules Age,BMI,HbAlc,UA,FBG,TC,TG,LDL-C were significantly higher than those without nodules,and HDL-C was lower than those without nodules,the difference was statistically significant(P<0.05);multivariate Logistic regression Analysis showed that age,UA,gender,and HbAlc were high-risk factors for the onset of thyroid nodules(P<0.05 and OR>1).Conclusion Age,UA,gender,and HbAlc are high-risk factors for the onset of thyroid nodules.For this group of people,thyroid ultrasonography should be strengthened to detect thyroid nodules early and implement treatment as soon as possible.