BiPAP呼吸机联合注射用牛肺表面活性剂治疗新生儿呼吸窘迫综合征的临床疗效

Clinical Efficacy of a BiPAP Ventilator Combined with Bovine Lung Surfactant For the Treatment of Neonatal Respiratory Distress Syndrome

目的分析经鼻双水平正压通气(BiPAP)呼吸机联合注射用牛肺表面活性剂治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法回顾性选取我院86例NRDS患儿(2017年1月至2020年6月),依照治疗方案不同分组。两组均接受注射用牛肺表面活性剂治疗,同时,对照组(42例)接受持续气道正压通气(NCPAP)联合治疗,观察组(44例)接受BiPAP呼吸机联合治疗,比较两组疗效、临床治疗情况(临床症状缓解时间、氧疗时间、无创通气时间、全肠道喂养时间、住院时间)、治疗前及治疗24 h后血气指标[二氧化碳分压(PaCO_(2))、氧分压(PaO_(2))]、并发症。结果两组治疗总有效率对比,观察组(95.45%)较对照组(71.43%)高(P<0.05);与对照组对比,观察组临床症状缓解、无创通气、氧疗、全肠道喂养、住院时间均较短(P<0.05);治疗24 h后,观察组PaCO_(2)较对照组低,PaO_(2)较对照组高(P<0.05);两组并发症发生率对比,无显著差异(P>0.05)。结论NRDS患儿接受BiPAP呼吸机联合注射用牛肺表面活性剂治疗,效果显著,能有效促进临床症状改善,缩短通气、氧疗、全肠道喂养、住院时间,调节血气指标,安全性高。

Objective To analyze the clinical efficacy of nasal double-level positive pressure ventilation(BiPAP)ventilator combined with cow lung surfactant in the treatment of neonatal respiratory distress syndrome(NRDS).Methods 86 children with NRDS(January 2017 to June 2020)were retrospectively selected and grouped according to the treatment protocol.Both groups were treated with cow lung surfactant for injection,control group(42 patients)received continuous positive airway pressure ventilation(NCPAP),observation group(44 patients)received BiPAP ventilator,compare efficacy,clinical treatment(clinical symptom relief time,oxygen therapy time,noninvasive ventilation time,whole intestinal feeding time,hospital time),blood gas index[24 h after treatment[carbon 2 partial pressure(PaCO_(2)),oxygen partial pressure(PaO_(2))],complications.Results Total treatment efficiency(95.45%)(P<0.05)(71.43%),short clinical symptoms,noninvasive ventilation,oxygen therapy,whole gut feeding,hospital stay(P<0.05);low PaCO_(2) after 24 h of treatment,high PaO_(2)(P<0.05)and no significant difference(P>0.05).Conclusion Children with NRDS were treated with BiPAP ventilator,which could effectively promote the improvement of clinical symptoms,shorten ventilation,oxygen therapy,whole intestinal feeding,hospital stay,regulate blood and gas index,and have high safety.