动物负重长骨牵张成骨模型建立与评估研究进展

Research progress in establishment and evaluation of animal weight-bearing long bone distraction osteogenesis model

牵张成骨技术临床应用广泛,建立动物模型是研究牵张成骨作用机制和促进骨及软组织再生方案的有效途径。目前,动物负重长骨牵张成骨模型建立尚无统一标准,这限制了对牵张成骨作用机制的深入研究。本文就动物负重长骨牵张成骨模型的建立与评估方案进行综述,为进一步研究牵张成骨提供参考。

The distraction osteogenesis is widely used in clinic,the establishment of animal model is an effective way to study the mechanism of distraction osteogenesis and to promote bone and soft tissue regeneration.At present,there is no unified standard for the establishment of animal weight-bearing long bone distraction osteogenesis model,which limits the in-depth understanding of the mechanism of distraction osteogenesis.Therefore,this paper reviews the establishment and evaluation of animal weight-bearing long bone distraction osteogenesis model,in order to provide reference for further study of distraction osteogenesis.