肝素钠雾化治疗婴儿喘息性支气管肺炎临床疗效

Clinical efficacy of heparin sodium nebulizer therapy for asthmatic bronchopneumonia in infants

目的观察婴儿喘息性支气管肺炎肝素钠雾化治疗的临床疗效。方法选取2019年11月至2021年1月在江西省景德镇市妇幼保健院儿科住院治疗的婴儿喘息性支气管肺炎患儿60例,依据随机数字表法分为对照组和观察组,每组各30例,首先给予对照组患者综合治疗,予患儿吸氧、化痰、镇静及抗感染治疗,给予患儿雾化吸入特布他林+普米克令舒解痉平喘等。然后观察组在对照组基础上雾化吸入0.50~0.75 mg/(kg·次)肝素钠注射液溶于生理盐水2 ml中,每日2~3次,每次5~10 min。用至喘息、气促缓解,肺部啰音由细小变为粗大,在此期间观察患儿是否有出血性迹象。然后统计分析两组患儿发热、咳嗽、喘息的持续时间和啰音、咳痰消失时间及住院时间、临床疗效。结果观察组患儿发热、咳嗽、喘息的持续时间和啰音、咳痰消失时间及住院时间均显著短于对照组,差异有统计学意义(P<0.05)。观察组患儿治疗的总有效率为96.67%(29/30),显著高于对照组的86.67%(26/30),差异有统计学意义(P<0.05)。结论婴儿喘息性支气管肺炎肝素钠雾化治疗的临床疗效显著。

Objective To observe the clinical efficacy of heparin sodium nebulizer therapy for asthmatic bronchopneumonia in infants.Methods A total of 60 infants with asthmatic bronchopneumonia who were hospitalized in the Department of Pediatrics of Jingdezhen Maternal and Child Health Hospital in Jiangxi Province from November 2019 to January 2021 were selected as the study subjects.They were divided into the control group and the observation group according to the random number table method,with 30 infants in each group.Firstly,the control group was given comprehensive treatment,including oxygen inhalation,phlegm-expelling and sedation,anti-infection treatment,and spasm and asthma reliving through nebulized inhalation of terbutaline+pulmicort respules.Then,the observation group was given nebulized inhalation of a 2 ml mixture of 0.50-0.75 mg/(kg·time)heparin sodium injection and normal saline on the basis of control group,with 2-3 times a day for 5-10 minutes each time.This treatment lasted until wheezing and shortness of breath were relieved and the lung rales changed from fine to coarse,during which the infants were observed for signs of bleeding.The duration of fever,cough,wheezing,and the time for the disappearance of rales and expectoration,as well as the length of stay and clinical efficacy of the two groups of infants were statistically analyzed.Results The duration of fever,cough,wheezing,and the time for the disappearance of rales and expectoration,as well as the length of stay of infants in the observation group were significantly shorter than those in the control group(P<0.05).The overall effective rate of treatment for infants in the observation group was 96.67%(29/30),which was significantly higher than that of 86.67%(26/30)in the control group(P<0.05).Conclusion The clinical efficacy of heparin sodium nebulizer therapy for infants with asthmatic bronchopneumonia is significant.