香菊胶囊联合布地奈德鼻喷雾剂治疗变应性鼻炎的疗效及对淋巴细胞亚群的影响

Efficacy of budesonide nasal spray combined with Xiangju Capsule in the treatment of allergic rhinitis and influence on lymphocyte subsets

目的探讨香菊胶囊联合布地奈德鼻喷雾剂治疗变应性鼻炎(AR)的疗效,并分析其对淋巴细胞亚群的影响。方法选取2018年3月~2020年9月我院收治的104例AR患者,随机分为治疗组和对照组,每组各52例。对照组给予布地奈德鼻喷雾剂治疗,治疗组在对照组基础上加用香菊胶囊治疗,治疗4周。治疗后记录两组有效率。对两组治疗前后鼻痒、鼻塞、流涕、喷嚏等症状采用视觉模拟评分法(VAS)评分进行评定,计算其症状总评分。治疗前后,检测血清白介素4(IL-4)、白介素8(IL-8)、γ-干扰素(IFN-γ)水平和T淋巴细胞亚群(CD_(3)^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平,并记录治疗过程中不良反应情况。结果治疗组有效率(96.15%)高于对照组(82.69%),差异有统计学意义(P<0.05)。治疗后,两组症状总评分和VAS评分均低于治疗前,且治疗组均低于对照组(P<0.05)。治疗后,两组血清IL-8及IL-4水平均低于治疗前,血清IFN-γ水平高于治疗前且均高于对照组,治疗组血清IL-4、IL-8水平均低于对照组(P<0.05)。治疗后治疗组CD8^(+)水平低于治疗前且均低于对照组,CD_(3)^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组且两组CD_(3)^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论香菊胶囊联合布地奈德鼻喷雾剂治疗AR患者疗效好,能够有效调节T淋巴细胞亚群比例,降低机体炎症反应,改善机体免疫功能,进而改善患者临床症状,安全可靠,值得推广。

Objective To investigate the effect of Xiang Ju capsule combined with Budesonide Nasal Spray on allergic rhinitis(AR)and analyze its effect on lymphocyte subsets.Methods A total of 104 patients with AR treated in our hospital from March 2018 to September 2020 were randomly divided into treatment group and control group,with 52 cases in each group.The control group was treated with Budesonide Nasal Spray.The treatment group was treated with Xiang Ju Capsule on the basis of the control group for 4 weeks.The effective rates of the two groups were recorded after treatment.The symptoms of sneezing,nasal congestion,runny nose and nasal itching were evaluated by value added service(VAS)before and after treatment,and the total symptom score was calculated.Before and after treatment,serum interleukin-4(IL-4),interleukin-8(IL-8)andγ-Interferon(IFN)-γLevels and T lymphocyte subsets(CD_(3)^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels,and adverse reactions during treatment were recorded.Results The effective rate of the treatment group(96.15%)was higher than that of the control group(82.69%)(P<0.05).After treatment,the VAS score and total symptom score of sneezing,nasal congestion,runny nose and nasal itching in the two groups were lower than those before treatment,and the treatment group was lower than that in the control group(P<0.05).After treatment,the levels of serum IL-4 and IL-8 in the two groups were lower than those before treatment-γ.The levels of serum IL-4 and IL-8 in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of CD_(3)^(+),CD4^(+),CD4^(+)/CD8^(+)in the treatment group were higher than those in the control group,and the levels of CD_(3)^(+),CD4^(+),CD4^(+)/CD8^(+)in the two groups were higher than those before treatment,and the level of CD8^(+)was lower than those in the control group and lower than those before treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiang Ju capsule combined with Budesonide Nasal Spray is effective in the treatment of AR.It can effectively regulate the proportion of T lymphocyte subsets,reduce the inflammatory reaction,improve the immune function,and improve the clinical symptoms of patients.It is safe and reliable,and is worthy of promotion.