血清维生素B_(6)与老年骨质疏松女性疾病严重程度相关性分析

Analysis on the correlation between serum vitamin B_(6) and disease severity in elderly women with osteoporosis

目的探讨与分析血清维生素B_(6)与老年骨质疏松女性疾病严重程度的相关性。方法选择2018年2月至2020年12月在江苏省靖江市人民医院诊治的老年女性60例为研究对象,判定骨质疏松发生情况与严重程度,检测血清维生素B_(6)含量并进行相关性分析。结果在60例女性中,判定为骨质疏松12例,骨量减低28例,骨量正常20例,不同严重程度患者的腰椎(L_(1~4))、左侧髋关节、股骨颈骨密度比较,差异有统计学意义(P<0.05)。骨质疏松与骨量减低患者的血清维生素B_(6)含量均低于骨量正常者(P<0.05),骨质疏松患者低于骨量减低者(P<0.05)。不同严重程度患者的吸烟、饮酒、腰臀比、血糖等比较,差异无统计学意义(P>0.05),年龄、体质量指数、骨质疏松家族史等比较,差异有统计学意义(P<0.05)。Spearman相关性显示,骨折疏松严重程度与维生素B_(6)、年龄、体质量指数、骨质疏松家族史等呈正相关(P<0.05)。logistic回归分析显示,维生素B_(6)、年龄、体质量指数、骨质疏松家族史均为影响老年骨质疏松女性疾病严重程度的重要因素(P<0.05)。结论本地区老年女性骨质疏松的患病率比较高,骨质疏松严重程度与血清维生素B_(6)存在相关性,血清维生素B_(6)是影响骨质疏松严重程度的重要因素。

Objective To explore and analyze the correlation between serum vitamin B_(6) and disease severity in elderly women with osteoporosis.Methods A total of 60 cases of elderly women who were treated in Jingjiang People’s Hospital from February 2018 to December 2020 were selected as study subjects.The development and severity of osteoporosis were determined,and serum vitamin B_(6) level was detected,and the correlation between serum vitamin B_(6) and the severity of osteoporosis was analyzed.Results In all the 60 female patients,12 patients were diagnosed with osteoporosis,28 patients were diagnosed with reduced bone mass,and 20 patients were diagnosed with normal bone mass.There were statistically significant differences in bone density of the lumbar spine(L_(1-4)),left hip joint,and femoral neck among patients with different severity(P<0.05).Serum vitamin B_(6) level was lower in both patients with osteoporosis and patients with reduced bone mass than in patients with normal bone mass(P<0.05),and the level was lower in patients with osteoporosis than in patients with reduced bone mass(P<0.05).There were no statistically significant differences in smoking,alcohol consumption,waist-to-hip ratio,and blood glucose level among patients with different severity(P>0.05),but there were statistically significant differences in age,body mass index,and family history of osteoporosis among patients with different severity(P<0.05).Spearman correlation analysis showed that severity of osteoporosis was positively correlated with vitamin B_(6),age,body mass index,and family history of osteoporosis(P<0.05).Logistic regression analysis showed that vitamin B_(6),age,body mass index,and family history of osteoporosis were all significant factors affecting the severity of osteoporosis in elderly women(P<0.05).Conclusion The prevalence of osteoporosis in elderly women in this region is relatively high.There is a correlation between the severity of osteoporosis and serum vitamin B_(6),and serum vitamin B_(6) is an important factor affecting the severity of osteoporosis.