摘要
阿尔茨海默病(Alzheimer disease,AD)作为一种以进行性认知功能障碍和行为损害为主要临床表现的进行性中枢神经系统(central nervous system,CNS)变性疾病,在老龄化加速的现代社会越来越受到重视[1-2]。AD的主要病理表现为β-淀粉样蛋白(amyloidβ-protein,Aβ)斑块的累积、tau蛋白神经原纤维缠结和系列神经炎症[3]。
Microglia are innate immune cells in the central nervous system,and their phagocytic activity plays an important role in neurodegenerative diseases such as Alzheimer disease(AD).In previous studies,microglia phagocytosis has been simply regarded as a beneficial treatment for AD.To some extent,the phagocytosis of AD pathological products by microglia can delay the disease progression.However,the effect of phagocytosis on microglia themselves is ignored.Excessive phagocytosis will lead to the damage of microglia,decline of phagocytosis,and even cause pro-inflammatory polarization of microglia and increase neurotoxicity.This article reviews the role and mechanism of microglial phagocytosis and discuss the effects of targeted regulation of microglial phagocytosis in different stages of AD,in order to provide some new ideas for the therapeutic strategy of AD.
作者
吴艺舸
王泽乾
殷丽君
戴瑶瑶
黄建军
宋丽娟
马存根
WU Yi-ge;WANG Ze-qian;YIN Li-jun;DAI Yao-yao;HUANG Jian-jun;SONG Li-juan;MA Cun-gen(The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Ad-ministration of Traditional Chinese Medicine,Research Center of Neurobiology,Shanxi University of Chinese Medicine,Jin-zhong 030619,China;Department of Neurosurgery,Sinopharm Tongmei General Hospital,Datong037003,China;De-partment of Physiology,Shanxi Medical University,Taiyuan 030032,China;Institute of Brain Science/Medical School,Shanxi Datong University,Datong 037009,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2022年第4期735-742,共8页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81473577
No.82004028)
中国博士后科学基金面上资助项目(No.2020M680912)
山西省应用基础研究计划项目(No.201901D211538)
山西省教育厅高等学校科技创新项目(No.2019L0734)
山西省卫健委医学科技领军团队(No.2020TD05)
山西省卫健委神经疾病防治研究重点实验室(No.2020SYS20)
山西中医药大学青年科学家培育项目(No.2021PY-QN-09)
山西中医药大学研究生创新创业项目(No.2021CX004
No.2021CX013)
山西中医药大学学科建设经费资助项目。
