摘要
The highly pathogenic and readily transmissible SARS-CoV-2 has caused a global coronavirus pandemic,urgently requiring effective countermeasures against its rapid expansion.All available vaccine platforms are being used to generate safe and effective COVID-19 vaccines.Here,we generated a live-attenuated candidate vaccine strain by serial passaging of a SARSCoV-2 clinical isolate in Vero cells.
基金
This work was supported by the National Key Research and Development Program of China(No.2020YFC0840900,2018YFA0900801 and 2020YFA0707500)
the Strategic Priority Research Program(XDB29010000,XDB37030000),CAS(YSBR-010)
the Emergency Key Programof Guangzhou Laboratory(No.EKPG21-09)
the Beijing Municipal Science and Technology Project(No.Z201100001020004,Z201100005420017)
the National Natural Science Foundation of China(No.82171820,No.12034006,and No.81921005)
C.-F.Q.was supported by the National Science Fund for Distinguished Young Scholars(81925025)
the Innovative Research Group(81621005)from the NSFC
the Innovation Fund forMedical Sciences(2019-I2 M-5-049)from the Chinese Academy of Medical Sciences.
