Lp-PLA2、copeptin水平对急性前循环脑梗死病情、预后的评估价值

The Evaluation Value of Lp-PLA2 and Copeptin Levels on the Condition and Prognosis of Patients with Acute Anterior Circulation Cerebral Infarction

目的:分析脂蛋白相关磷脂酶A2(Lipoprotein associated phospholipase A2,Lp-PLA2)、血清和肽素(copeptin)水平对急性前循环脑梗死病情、预后的评估价值。方法:收集本院98例急性前循环脑梗死患者的临床资料(研究组)。同期选取本院行健康体检者42例(对照组)。比较两组Lp-PLA2、copeptin水平;根据脑梗死患者病情严重程度进行分组,比较不同病情脑梗死患者Lp-PLA2、copeptin水平变化情况;并分析影响其预后死亡的危险因素。结果:研究组Lp-PLA2、copeptin水平均显著高于对照组(P<0.05);随着脑梗死患者病情进展,Lp-PLA2、copeptin水平逐渐上升(P<0.05)。对患者进行3个月随访,发现死亡5例(5.10%),存活93例(94.90%)。死亡组糖化血红蛋白、Lp-PLA2、copeptin水平显著高于存活组,且死亡组多合并糖尿病史、房颤(P<0.05);且经Logistic回归分析,患者合并糖尿病、房颤及糖化血红蛋白、Lp-PLA2、copeptin水平升高是急性前循环脑梗死患者预后死亡的独立因素(P<0.05)。结论:Lp-PLA2、copeptin是与急性前循环脑梗死有关的标志物,通过检测上述因子水平可有效评估病情的严重程度、患者预后,给临床防治提供新思路。

Objective:To analyze the value of lipoprotein associated phospholipase A2(Lp-PLA2),serum copeptin levels in the evaluation of the condition and prognosis of patients with acute anterior circulation cerebral infarction.Methods:The clinical data of 98 patients(study group)with acute anterior circulation cerebral infarction in our hospital were collected.During the same period,42 patients(control group)with health examination were selected in our hospital.The levels of Lp-PLA2 and copeptin were compared between the two groups.According to the severity of cerebral infarction,patients were divided into groups.The changes of Lp-PLA2 and copeptin levels in patients with cerebral infarction at different conditions were compared.The risk factors that affect the prognosis of death were analyzed.Results:The levels of Lp-PLA2 and copeptin in the study group were significantly higher than those in the control group(P<0.05).With the development of patients with cerebral infarction,the levels of Lp-PLA2 and copeptin gradually increased(P<0.05).The patients were followed up for 3 months,and 5 cases(5.10%)died,93 cases(94.90%)survived.The levels of glycosylated hemoglobin,Lp-PLA2 and copeptin in the death group were significantly higher than those in the survival group.And the patients in the death group mostly had diabetes history and atrial fibrillation(P<0.05).And Logistic regression analysis showed that combined diabetes,atrial fibrillation,and increased levels of glycosylated hemoglobin,Lp-PLA2,and copeptin are independent factors for the prognosis of death in patients with acute anterior circulation cerebral infarction(P<0.05).Conclusion:Lp-PLA2 and copeptin are markers that are related to acute anterior circulation cerebral infarction.By detecting the levels of the above factors,the severity of the disease and the prognosis of the patient can be effectively evaluated,which can provide new ideas for clinical prevention and treatment.