摘要
神经内分泌肿瘤(NENs)起源于全身弥漫分布的神经内分泌细胞,临床上易误诊、漏诊,给临床诊治带来巨大困难,严重影响其预后。本文将从NENs的实验室及病理检查、内镜诊治、生长抑素、免疫检查点抑制剂、肽受体放射性核素治疗等方面介绍NENs诊治的难点和热点,旨在为NENs早诊早治、中晚期高级别NENs的规范化诊治提供思路,为临床多学科专家对NENs综合处理提供更多策略。
Neuroendocrine neoplasms(NENs)originate from neuroendocrine cells diffusely distributed throughout the body.NENs are liable to be misdiagnosed and missed clinically,which brings great difficulties to clinical diagnosis and treatment,and seriously affects their prognosis.This article will introduce the difficulties and hot spots in the diagnosis and treatment of NENs from the aspects of laboratory and pathological examinations,anatomical and functional imaging examinations,including endoscopy,peptide receptor radionuclide therapy,somatostatin analogue and immune checkpoint inhibitor therapy.It aims to provide more ideas for the early diagnosis and early treatment of NENs,standardized diagnosis and treatment of high-grade NENs in the middle and late stages,and to provide more strategies for clinical multidisciplinary experts towards the management of focused dilemmas in NENs.
作者
汤琪云
王峰
刘云
Tang Qiyun;Wang Feng;Liu Yun(Department of Geriatric Gastroenterology,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Nuclear Medicine,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Geriatrics,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2022年第14期977-981,共5页
National Medical Journal of China
基金
江苏省医学重点人才项目(ZDRCA2016008)。
关键词
神经内分泌瘤
内镜
生长抑素
免疫检查点抑制剂
肽受体放射性核素治疗
Neuroendocrine tumors
Endoscopy
Somatostatin analogue
Immune checkpoint inhibitors
Peptide receptor radionuclide therapy
