考虑质量扩散的瘤内磁流体分布对磁热疗影响研究

Effect of intratumoral nanofluid distribution on magnetic hyperthermia considering mass diffusion

通过比较磁纳米颗粒在体内的理想均匀分布和真实实验分布,研究了不同纳米流体分布对治疗温度的影响,其中真实分布来源于实验结果经本文所提出方法处理后的图像分布。同时,还进一步研究了纳米流体扩散行为对浓度分布的影响,以及研究了温度依赖性的血液灌注率和传统定值灌注率对治疗温度分布影响的差异。本研究基于热等效应剂量的角度,通过43℃下的累积等效分钟数来评估磁流体热疗的治疗效果,该方法与治疗温度分布直接相关。模拟结果表明,在考虑单个磁性纳米颗粒临界功率耗散的情况下,纳米流体扩散对肿瘤区域内纳米流体分布的均匀度具有积极的影响,而对最终治疗温度的影响则较小。

This article investigates the influence of different nanofluid distributions on the treatment temperature by considering a homogeneous distribution of magnetic nanoparticles(MNPs).Two distributions are observed in experimental images and modeled by the proposed method in this article.Meanwhile,the effect of nanofluid diffusion on the concentration distribution is further studied.In addition,the difference of temperature-based on the blood perfusion rate and the traditional quantitative perfusion rate is also considered.The treatment effect in this study is evaluated by the cumulative equivalent minutes at 43℃(CEM43)from the perspective of the thermal iso-effect dose,which is directly related to the treatment temperature distribution.Simulation results demonstrate that the nanofluid diffusion has positive effect on the uniformity degree of nanofluid distribution inside tumor region,while it has less effect on the ultimate treatment temperature if individual critical power dissipations of MNPs.