复方川芎胶囊联合阿罗洛尔治疗心绞痛的临床研究

Clinical study on Compound Chuanxiong Capsules combined with arotinolol hydrochloride in treatment of angina pectoris

目的 探讨复方川芎胶囊联合盐酸阿罗洛尔片治疗心绞痛的临床疗效。方法 选择2020年6月-2021年6月在濮阳市油田总医院治疗的118例心绞痛患者,根据用药的差别分为对照组和治疗组,每组各59例。对照组口服盐酸阿罗洛尔片,10 mg/次,1次/d;治疗组在对照组基础上口服复方川芎胶囊,4粒/次,3次/d。两组均经8周治疗。观察两组患者临床疗效,比较治疗前后两组患者心绞痛发作次数和持续时间,SAQ、GQOLI-74和Duke评分,及血清血管性血友病因子(v WF)、人正五聚蛋白3(PTX3)、血管细胞黏附分子1(VCAM1)、血管内皮生长因子(VEGF)和转化生长因子β结合蛋白2(LTBP2)水平。结果 经治疗,治疗组总有效率明显高于对照组(98.31%vs 86.44%,P<0.05)。治疗后,两组患者心绞痛发作次数、持续时间均减少(P<0.05),且治疗组比对照组减少更明显(P<0.05)。经治疗,两组患者SAQ评分、GQOLI-74评分、Duke评分均明显升高(P<0.05),且治疗组明显高于对照组(P<0.05)。治疗后,两组v WF、PTX-3、VCAM-1、LTBP-2水平明显降低,而VEGF水平升高(P<0.05),且治疗组血清学指标改善优于对照组(P<0.05)。结论 复方川芎胶囊联合盐酸阿罗洛尔片治疗心绞痛,不仅促进症状改善,还能够促进机体细胞因子和生活质量的改善,具有一定临床推广应用价值。

Objective To explore the clinical efficacy of Compound Chuanxiong Capsules combined with arotinolol hydrochloride in treatment of angina pectoris. Methods Patients(118 cases) with angina pectoris in Puyang Oilfield General Hospital from June 2020 to June 2021 were divided into control and treatment group based on different treatments, and each group had 59 cases. Patients in the control group were po administered with Arotinolol Hydrochloride Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Compound Chuanxiong Capsules on the basis of the control group, 6 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, the frequency and duration of angina pectoris,scores of SAQ, GQOLI-74, and Duke, the levels of serological indexes vWF, PTX-3, VCAM-1, VEGF, and LTBP-2 in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was significantly higher than that of the control group(98.31% vs 86.44%, P < 0.05). After treatment, the attack times and duration of angina pectoris were significantly decreased in two groups(P < 0.05), and the times and duration of angina pectoris in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the scores of SAQ, GQOLI-74 and Duke in two groups were significantly increased(P < 0.05), and which in the treatment group were significantly higher than those in the control group(P < 0.05). After treatment, the levels of vWF, PTX-3, VCAM-1 and LTBP-2 in both groups were significantly decreased, while the level of VEGF was increased(P < 0.05), and the improvement of serological indexes in the treatment group was better than that in the control group(P < 0.05). Conclusion Compound Chuanxiong Capsules combined with arotinolol hydrochloride in treatment of angina pectoris can not only pro mote the improvement of symptoms, but also promote the improvement of cytokines and quality of life, which has a certain clinical application value.