儿童清咽解热口服液联合头孢克肟治疗小儿急性咽炎的临床研究

Clinical study on Ertong Qingyan Jiere Oral Liquid combined with cefixime in treatment of acute pharyngitis in children

目的 探讨儿童清咽解热口服液联合头孢克肟颗粒治疗小儿急性咽炎的临床疗效。方法 选取2020年2月-2021年10月开封市儿童医院收治的80例急性咽炎患儿,根据随机数字表法将所有患儿分为对照组和治疗组,每组各40例。对照组口服头孢克肟颗粒,2.0 mg/kg,2次/d。治疗组在对照组基础上口服儿童清咽解热口服液,3岁:0.5支/次,4~7岁:1支/次,7岁以上:1.5支/次;3次/d。两组在治疗5 d后统计疗效。观察两组的疗效,比较两组患儿主要症状体征消退时间、血液炎症指标水平。结果 治疗后,治疗组患儿的总有效率(95.00%)明显高于对照组(77.50%)(P<0.05)。治疗后,治疗组的发热、咽痛、咽部红肿、咯痰消退时间比对照组更短(P<0.05)。治疗后,两组的CD64、C反应蛋白(CRP)、白细胞计数(WBC)较治疗前明显减少(P<0.05),且治疗组CD64、CRP、WBC较对照组降低更明显,差异具有统计学意义(P<0.05)。结论 儿童清咽解热口服液联合头孢克肟颗粒治疗小儿急性咽炎的疗效确切,能减轻临床症状,降低炎症反应,药物安全性较好。

Objective To investigate the clinical efficacy of Ertong Qingyan Jiere Oral Liquid combined with Cefixime Granules in treatment of acute pharyngitis in children. Methods Children(80 cases) with acute pharyngitis in Kaifeng Children’s Hospital from February 2020 to October 2021 were randomly divided into control and treatment groups, and each group had 40 cases. Children in the control group were po administered with Cefixime Granules, 2.0 mg/kg, twice daily. Children in the treatment group were po administered with Ertong Qingyan Jiere Oral Liquid on the basis of the control group, 3 years old: 0.5 pieces/time, 4 — 7 years old: 1 piece/time, over 7 years old: 1.5 pieces/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and the regression time of main symptoms and signs, and the serum level of inflammatory factor in two groups were compared. Results After treatment, the total effective rate of children in the treatment group(95.00%) was significantly higher than that in the control group(77.50%)(P < 0.05). After treatment, the regression time of fever, pharyngeal pain, pharyngeal swelling, and expectoration in the treatment group was shorter than that in the control group(P < 0.05). After treatment, the CD64,CRP, and WBC in two groups were significantly lower than those before treatment(P < 0.05), and the CD64, CRP, and WBC in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Ertong Qingyan Jiere Oral Liquid combined with Cefixime Granules is effective in treatment of acute pharyngitis in children, can improve clinical symptoms and reduce inflammatory reaction with good safety.