嗜酸性粒细胞胞外诱捕网在慢性气道疾病发病机制中的作用

Role of eosinophil extracellular traps in the pathogenesis of chronic airway diseases

嗜酸性粒细胞胞外诱捕网(eosinophil extracellular traps,EETs)由DNA纤维、组蛋白及嗜酸性粒细胞游离颗粒组成,是嗜酸性粒细胞发挥作用的重要途径。最近研究显示EETs在多种呼吸系统疾病例如哮喘、变应性支气管肺曲霉病及慢性阻塞性肺疾病的发生发展过程中都发挥重要作用,EETs可通过直接破坏气道上皮细胞,促进气道高分泌及炎症反应,增加分泌物黏稠度及诱导机体产生自身抗体等途径参与疾病的发生发展,针对EETs的研究也将有助于开发治疗相关疾病的新靶点。

Eosinophil extracellular traps(EETs),an important pathway of eosinophil to exert its effects,are composed of DNA fibers,histone and eosinophil granule proteins.Recently,many researches have shown that EETs play an important role in the genesis and development of respiratory diseases including asthma,allergic bronchopulmonary aspergillosis and chronic obstructive pulmonary disease.EETs can directly damage airway epithelial cells,promote airway inflammation and airway hypersecretion,increase the stickiness of secretions and induce the generation of autoantibody,helping eosinophils and their products participate in a cascade of events leading to inflammation and disease.Researches on EETs can also be helpful in investigating new targets for the treatment of chronic airway diseases.