Age-specific microbiota in altering host inflammatory and metabolic signaling and metabolome based on sex

We read the recent study,“Age-specific microbiota in altering host inflammatory and metabolic signaling as well as metabolome based on the sex”,published in Hepatobiliary Surgery and Nutrition about the effects of sex-dependent changes in gut microbiota on age-related metabolic disease(1).The authors examined the relationships between fecal microbiota and age-dependent metabolic phenotypes in both sexes and demonstrated the efficacy of fecal microbiota transplantation(FMT)in altering insulin sensitivity depending on the sex of the recipients.