转化生长因子β诱导基因在胃癌中的表达及临床意义

Expression and its clinical significance of TGFBI in gastric cancer

目的研究转化生长因子β诱导基因(TGFBI)在胃癌组织中的表达水平及临床意义。方法收集2019年12月至2020年12月在青海大学附属医院经胃镜检查及病理活组织检查后明确诊断为胃腺癌的患者87例,取胃癌组织及配对癌旁组织标本,应用实时荧光定量PCR技术检测TGFBI在胃癌组织中的相对表达量,分析其与临床病理参数的关系。结果TGFBI在胃癌组织中的相对表达量[0.613(0.263,0.884)]显著高于配对癌旁组织中的相对表达量[0.282(0.141,0.353)],差异有统计学意义(Z=4.457,P<0.01);胃癌组织中TGFBI的相对表达量在肿瘤不同分化程度、浸润深度间差异有统计学意义(P<0.05,P<0.01)。结论TGFBI表达水平与胃癌的发生发展相关,可以作为一种胃癌的生物学标记物,为胃癌的分子靶向治疗提供参考依据。

Objective To investigate the expression level and clinical significance of transforming growth factor β-induced gene(TGFBI)in gastric cancer tissue.Methods The samples of cancerous tissue and paired adjacent tissue were collected from 87 patients who were confirmed with gastric cancer after gastroscopy and pathological biopsy from December 2019 to December 2020 in Affiliated Hospital of Qinghai University.The relative expression levels of TGFBI in gastric cancer tissues were detected by RT-qPCR,and the correlation between TGFBI and clinicopathological parameters was analyzed.Results The relative expression of TGFBI in gastric cancer tissue[0.613(0.263,0.884)]was significantly higher than that in paired adjacent tissue[0.282(0.141,0.353)],and the difference was statistically significant(Z=4.457,P<0.01);The expression level of TGFBI in gastric cancer tissues was significantly associated with the degree of tumor differentiation and the depth of invasion(P<0.05,P<0.01).Conclusion TGFBI expression level is related to the occurrence and development of gastric cancer and may be used as a biological marker for gastric cancer,so as to provide theoretical basis for the therapeutic target in gastric cancer.