摘要
异相睡眠剥夺(PSD)与术后疼痛的发生密切相关,其机制尚未明确。近年来研究发现,脑源性神经营养因子(BDNF)是PSD的重要调节因子。BDNF/酪氨酸激酶受体B(TrkB)信号通路在PSD致术后痛觉敏化中的作用也被逐渐认识,本文对BDNF/TrkB通路参与PSD致术后痛觉敏化的相关研究现状做一综述,以期为PSD致术后痛觉敏化的临床预防及治疗提供新方向。
Paradoxical sleep deprivation is closely related to postoperative pain.However,its underlying mechanism is unclear.In recent years,studies have found brain-derived neurotrophic factor(BDNF)is an important regulator of PSD,and the role of BDNF/tyrosine kinase receptor B(TrkB)signaling pathway in postoperative pain sensitization after PSD has also been gradually recognized.This article will review the related research progress of BDNF/TrkB signaling pathway involved in PSD-induced postoperative pain sensitization,in order to provide a new direction for the clinical prevention and treatment of postoperative pain sensitization caused by PSD.
作者
张杰
李文娟
薛阳
薛建军
ZHANG Jie;LI Wen-juan;XUE Yang;XUE Jian-jun(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou,Gansu 730000,China;不详)
出处
《中国临床研究》
CAS
2022年第4期556-559,共4页
Chinese Journal of Clinical Research
基金
甘肃省自然科学基金项目(21JR7RA586)
甘肃省科技计划项目(20JR10RA435)。
关键词
脑源性神经营养因子/酪氨酸激酶受体B信号通路
术后疼痛
异相睡眠剥夺
痛觉敏化
Brain-derived neurotrophic factor/tyrosine kinase receptor B signaling pathway
Postoperative pain
Paradoxical sleep deprivation
Pain sensitization
