高尿酸血症对慢性肾脏病及合并症影响的研究进展

Research Progress of Hyperuricemia on Chronic Kidney Disease and Complications

正常情况下,血尿酸水平在人体内保持动态平衡,尿酸排泄主要通过肾脏,其次在肠道,当人体血尿酸的动态平衡被破坏时会导致高尿酸血症。目前临床研究表明,高尿酸血症在慢性肾脏病的发生发展中具有重要的影响,并且共患病加速了慢性肾脏病合并症的发生发展和死亡风险。本文就尿酸代谢及高尿酸血症概述、高尿酸血症对慢性肾脏病和合并症的影响及对慢性肾脏病患者的降尿酸治疗影响及进展等方面作一综述。

Normally,the level of serum uric acid maintains a dynamic balance in the human body.The excretion of uric acid is mainly through the kidney,followed by the intestinal tract.Hyperuricemia will occur when the dynamic balance of serum uric acid destroyed.Current clinical studies have shown that hyperuricemia has an important impact on the occurrence and development of chronic kidney disease,and comorbidity accelerates the occurrence and development of chronic kidney disease complications and the risk of death.This article reviews the metabolism of uric acid and hyperuricemia,the effect of hyperuricemia on chronic kidney disease and complications,and the effect and progress of lowering uric acid in patients with chronic kidney disease.