摘要
目的探讨卵巢子宫内膜异位症(EMS)患者血清抗苗勒氏管激素(AMH)水平变化及手术对卵巢储备功能的影响。方法选择2019年1月-12月在浙江大学医学院附属妇产科医院收治并确诊的卵巢子宫内膜异位症患者422例,均行腹腔镜下子宫内膜异位症囊肿摘除手术,设为EMS组;根据卵巢受累情况分单侧和双侧EMS。另选取同期232例健康女性设为对照组。采用电化学发光法检测两组血清AMH水平,比较EMS组手术前后、EMS组卵巢不同受累情况、不同临床分期及对照组血清AMH水平。结果EMS组双侧血清AMH水平低于单侧和对照组(P<0.05);EMS组双侧Ⅲ~Ⅳ期血清AMH水平较Ⅰ~Ⅱ期和对照组低,差异有统计学意义(P<0.05);EMS组术后AMH水平较术前下降(P<0.05)。结论双侧卵巢子宫内膜异位症会降低患者的卵巢储备功能,临床分期级别较高(Ⅲ~Ⅳ期)相较于低级别(Ⅰ~Ⅱ期)对卵巢储备功能影响较大,腹腔镜下子宫内膜异位症囊肿摘除术短期内可能对卵巢储备功能有影响。
Objective To investigate the changes of serum anti-müllerian hormone(AMH)levels in patients with ovarian endometriosis(EMS)and the impact of surgery on ovarian reserve function.Methods A total of 422 patients with ovarian endometriosis who were diagnosed in Women’s Hospital,School of Medicine,Zhejiang University from January 2019 to December 2019 were selected as EMS group,and all patients underwent laparoscopic endometriosis cystectomy.According to the ovarian involvement,they were divided into unilateral and bilateral EMS.Another 232 healthy women were selected as control group at the same time.The serum AMH levels of the two groups were detected by electrochemiluminescence method.Serum AMH levels were compared before and after operation in EMS group,different ovarian involvement,different clinical stages and control group.Results The serum AMH level of patients with bilateral EMS was significantly lower than that of patients with unilateral EMS and control group(P<0.05).The serum AMH level of patients with bilateral Ⅲ-Ⅳ EMS was lower than that of patients with Ⅰ-Ⅱ EMS and control group(P<0.05).In addition,the level of AMH in EMS patients decreased significantly after operation(P<0.05).Conclusion Bilateral ovarian endometriosis can reduce the ovarian reserve function of patients.Higher clinical stage(stage Ⅲ-Ⅳ)has a greater impact on ovarian reserve function than lower clinical stage(stage Ⅰ-Ⅱ).Laparoscopic endometriosis cystectomy has an impact on ovarian reserve function.
作者
陈斐
吴开奇
CHEN Fei;WU Kai-qi(Department of Clinical Laboratory,Women's Hopital,School of Medicine,Zhejiang University,Hangzhou 310006,Zhejiang,China)
出处
《医学信息》
2022年第7期145-147,共3页
Journal of Medical Information
