PTPRD单核苷酸多态性与不宁腿综合征相关性的Meta分析

Association of single nucleotide polymorphisms of PTPRD and restless legs syndrome:a Meta-analysis

目的探讨PTPRD基因上的2个单核苷酸多态性rs1975197和rs4626664与不宁腿综合征的相关性。方法检索有关rs1975197的4项研究和rs4626664的5项研究,按照纳入和排除标准提取每项研究的基本信息。Meta分析用于分析比值比(odds ratio,OR)和95%可信区间(confidence interval,CI)。森林图用于直观地评估异质性。如果存在异质性,则采用亚组分析。漏斗图用于直观地评估发表偏倚。结果rs1975197的T等位基因可增加高加索人不宁腿综合征的风险(OR=1.43,95%CI 1.13~1.80)。而在rs4626664的研究中,总体分析和亚组分析均无统计学意义。结论Meta分析显示rs1975197的T等位基因增加了高加索人不宁腿综合征的风险,具有一定的种族特异性,今后需要开展包括不同种族在内的更多更大规模的病例对照研究来明确PTPRD基因与不宁腿综合征的相关性。

Objective The aim of the study is to investigate the association of rs1975197 and rs4626664 of PTPRD and restless legs syndrome(RLS).Methods We retrieved 4 studies on rs1975197 and 5 studies of rs4626664 and extracted basic information of each study following inclusion and exclusion criteria.Meta-analysis was used to analyze odds ratio(OR)and 95%confidence intervals(CI).Forest plots were used to assess heterogeneity visually.If heterogeneity existed,subgroup analysis would be used.Funnel plots was used to assess publication bias visually.Results As for rs1975197,T allele could increase the risk of RLS in Caucasian(OR=1.43,95%CI 1.13~1.80).However,there were no statistically significant of rs4626664 observed in neither overall analysis nor subgroup analysis.Conclusion T allele of rs1975197 of PTPRD increases the risk of RLS in Caucasian using Meta-Analysis,suggesting a race specificity of PTPRD with RLS.More and larger case-control studies including different races need to be launched for investigating the association of PTPRD with RLS.