治疗前肝功能指标对吉兰-巴雷综合征患者疾病严重程度及预后的预测价值

Predictive value of pre-treatment liver function indexes on the clinical severity at nadir and prognosis of patients with Guillain-BarréSyndrome

目的探讨治疗前肝功能指标对吉兰-巴雷综合征(Guillain-Barrésyndrome,GBS)患者疾病严重程度及预后的预测价值。方法回顾性分析2010年1月至2016年9月在济宁医学院附属医院住院的206例GBS患者临床资料,采用多因素Logistic回归分析影响GBS患者疾病严重程度和预后的独立因素,以受试者工作特征曲线(receiver operator characteristic curve,ROC)评价治疗前肝功能指标对GBS患者疾病严重程度及预后的预测价值。结果治疗前肝功能指标中的白蛋白、白/球比、GGT、球麻痹是影响GBS患者高峰期疾病严重程度的危险因素(均P<0.05);白蛋白、GGT、机械通气是影响GBS患者预后的危险因素(P值均<0.05)。结论白蛋白和GGT具有预测GBS患者高峰期病情以及预后的价值。

Objective To explore the predictive value of liver function indexes on the clinical severity at nadir and prognosis of patients with Guillain-BarréSyndrome(GBS).Methods The clinical data of 206 GBS patients hospitalized in the affiliated hospital of Jining Medical University from January 2010 to September 2016 were analyzed retrospectively.Multivariate logistic regression analysis was used to analyze the independent factors affecting the severity and prognosis of GBS patients.The receiver operator characteristic curve(ROC)was used to evaluate the predictive value of pre-treatment liver function indexes on the severity at nadir and prognosis of GBS patients.Results Albumin,A/G ratio,GGT,and ball palsy were the risk factors that affected the severity of disease in GBS patients at the peak(all P<0.05);albumin,GGT,and mechanical ventilation were the risk factors for prognosis of GBS patients(all P values<0.05).Conclusion Albumin and GGT have potentials to predict clinical severity at nadir and outcome at 6 months in patients with GBS.