基于胰岛巨噬细胞-胰腺脂肪细胞-胰岛β细胞网络探讨针刺治疗2型糖尿病机制

Investigation on the mechanism of acupuncture in treatment of diabetes mellitus type 2 based on the network of islet macrophages-pancreatic adipose cells-isletβcells

以胰岛炎性反应为基点,探讨针刺治疗2型糖尿病(T2DM)的可能新机制。胰岛巨噬细胞、胰腺脂肪细胞及胰岛β细胞均参与T2DM的发病过程,且三者可构成网络交互。而针刺可调节胰岛巨噬细胞功能表型、改善胰腺脂肪异位沉积及修复胰岛β细胞功能,并发挥整体调节的独特优势,提示针刺可成为T2DM潜在的治疗策略。

To explore the possible new mechanism of acupuncture in the treatment of diabetes mellitus type 2(T2DM)based on the islet inflammatory response.Islet macrophages,pancreatic adipose cells and isletβcells all participate in the pathogenesis of T2DM,and the three could form a network interaction.Acupuncture could regulate the functional phenotype of islet macrophages,improve the ectopic deposition of pancreatic adipose and repair the function of isletβcells,and play a unique advantage of overall regulation.It is suggested that acupuncture can be a potential treatment strategy for T2DM.